{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:13:48Z","timestamp":1760015628287},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"With the aim of standardizing K<\/jats:styled-content>i\u201067 immunohistochemistry, we assessed interobserver and interlaboratory variability of the K<\/jats:styled-content>i\u201067 labeling index and K<\/jats:styled-content>i\u201067 score among eight general pathologists for 24 gastrointestinal stromal tumors (GISTs<\/jats:styled-content>) and 12 leiomyosarcomas, which were predominantly of the gastrointestinal (GI<\/jats:styled-content>) tract, mesentery and retroperitoneum, based on a review of a tissue microarrays subjected to immunohistochemistry with antibodies for K<\/jats:styled-content>i\u201067. For K<\/jats:styled-content>i\u201067 immunostaining of mesenchymal tumors of the GI<\/jats:styled-content> tract, including GISTs<\/jats:styled-content>, differences were seen in the scores given by regional hospitals. Conversely, for two categories of the K<\/jats:styled-content>i\u201067 labeling index, namely <10% and \u226510%, concordance of the K<\/jats:styled-content>i\u201067 score between microscopic observation and image analysis, and between the observers, was good, but it was not good for the other four categories of the index for <5%, 5\u20139%, 10\u201329%, and \u226530%. The concordance of the K<\/jats:styled-content>i\u201067 scores between the observers in two categories was higher using the K<\/jats:styled-content>i\u201067 pre\u2010stained tissue microarrays (TMAs)<\/jats:styled-content> within each participating institute than that using the K<\/jats:styled-content>i\u201067 stained TMAs<\/jats:styled-content> between the participating institutes. The reproducibility of a 10% cut\u2010off value for the K<\/jats:styled-content>i\u201067 labeling index to predict the prognosis of GISTs<\/jats:styled-content> was relatively high, but there is an urgent need to standardize the staining technique.<\/jats:p>","DOI":"10.1111\/pin.12038","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T08:39:27Z","timestamp":1361522367000},"page":"102-107","source":"Crossref","is-referenced-by-count":12,"title":["Validity and reproducibility of K<\/scp>i\u201067 assessment in gastrointestinal stromal tumors and leiomyosarcomas"],"prefix":"10.1111","volume":"63","author":[{"given":"Jiro","family":"Ogino","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Asanuma","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo 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