{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:39:04Z","timestamp":1791005944858,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Systemic lupus erythematosus (SLE<\/jats:styled-content>) and pregnancy\u2010induced hypertension (PIH<\/jats:styled-content>) are related to premature delivery and intrauterine growth restriction (IUGR<\/jats:styled-content>), and share histological findings of the placenta. Association with complement dysregulation has been reported in pregnancy for both disorders. The purpose of this study was to investigate the utility of C<\/jats:styled-content>4d immunohistochemistry for placentas with SLE<\/jats:styled-content>\u2010 and PIH<\/jats:styled-content>\u2010associated pregnancy. C4d staining was performed on paraffin\u2010embedded tissue of placentas from 26 patients with SLE<\/jats:styled-content>, 26 with PIH<\/jats:styled-content>, and 25 control cases. We used the H<\/jats:styled-content>\u2010score with a range of 0\u2013300 for the evaluation of C<\/jats:styled-content>4d immunoreactivity. Placentas of SLE<\/jats:styled-content> and PIH<\/jats:styled-content> cases showed a higher H<\/jats:styled-content>\u2010score than control cases (average, SLE<\/jats:styled-content>, 38.3 (P<\/jats:italic> < 0.05); PIH<\/jats:styled-content>, 17.8; control, 1.68), with linear staining on the membrane of syncytiotrophoblast. C4d\u2010high groups comprised 50% (12\/26) of SLE<\/jats:styled-content> and 35% (9\/26) of PIH<\/jats:styled-content> cases, with H<\/jats:styled-content>\u2010scores ranging 14\u2013270 and 15\u2013170. C4d\u2010high groups were significantly associated with low\u2010placental weights and low birth weight in both SLE<\/jats:styled-content> and PIH<\/jats:styled-content> (P<\/jats:italic> < 0.05), and lower gestational age (P<\/jats:italic> < 0.05) in PIH<\/jats:styled-content> cases. These results suggest that C<\/jats:styled-content>4d might be utilized as a biomarker evaluating the subsequent risk for IUGR<\/jats:styled-content> and disease control during the gestation period in these patients.<\/jats:p>","DOI":"10.1111\/pin.12041","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T02:31:44Z","timestamp":1364351504000},"page":"150-157","source":"Crossref","is-referenced-by-count":25,"title":["Complement split product C<\/scp>4d deposition in placenta in systemic lupus erythematosus and pregnancy\u2010induced hypertension"],"prefix":"10.1111","volume":"63","author":[{"given":"Sachiko","family":"Minamiguchi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Kyoto 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