{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:06:25Z","timestamp":1790485585365,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Acute megakaryoblastic leukaemia (<jats:styled-content style=\"fixed-case\">AMGL<\/jats:styled-content>) is an uncommon disease with poor prognosis. Histopathologically, <jats:styled-content style=\"fixed-case\">AMGL<\/jats:styled-content> cases show variable degree of fibrosis and the presence of uniform blasts or mature dysplastic megakaryocytes. Here we examined 18 cases of <jats:styled-content style=\"fixed-case\">AMGL<\/jats:styled-content>, including idiopathic (<jats:italic>n<\/jats:italic> = 9) and secondary (<jats:italic>n<\/jats:italic> = 9) cases. Fourteen cases were males and four were females, ranging in age from 14 to 87 years (median, 58). All cases had anaemia, but leukocyte and platelet counts varied. Blast cells were detected in the peripheral blood of 14 cases. Fourteen of 16 cases showed chromosomal abnormalities. The median survival was 6 months (range, 1\u201348 months). Survival rates did not correlate with the severity of fibrosis, proportion of blast cells and cause of <jats:styled-content style=\"fixed-case\">AMGL<\/jats:styled-content>. Nine of the 11 cases examined immunohistochemically were positive for platelet\u2010derived growth factor (<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>)(\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>), especially megakaryoblasts and a few fibroblasts. The <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010positive cases showed various degrees of fibrosis, while the negative cases showed no evidence of fibrosis. Our results confirmed the poor prognosis of patients with <jats:styled-content style=\"fixed-case\">AMGL<\/jats:styled-content>, irrespective of the degrees of fibrosis, and demonstrated that <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> could play an important role in the pathogenesis of marrow fibrosis.<\/jats:p>","DOI":"10.1111\/pin.12043","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T02:31:44Z","timestamp":1364351504000},"page":"141-149","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological features of acute megakaryoblastic leukaemia: Relationship between fibrosis and platelet\u2010derived growth factor"],"prefix":"10.1111","volume":"63","author":[{"given":"Daisuke","family":"Niino","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Hematology and Molecular Medicine Atomic Disease Institute Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"Japan Red Cross Nagasaki Genbaku Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Molecular Medicine Atomic Disease Institute Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"130","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Arber DA","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90733-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb04730.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(82)91941-6"},{"key":"e_1_2_5_6_1","first-page":"6","article-title":"Structural and functional aspects of platelet\u2010derived growth factor and its receptors","volume":"150","author":"Westermark B","year":"1990","journal-title":"Ciba Found Symp"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/304035a0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.3.731"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.4.1304"},{"key":"e_1_2_5_10_1","first-page":"1128","article-title":"European consensus on grading bone marrow fibrosis and assessment of cellularity","volume":"90","author":"Thiele J","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00153-3"},{"key":"e_1_2_5_12_1","first-page":"1851","article-title":"Megakaryoblastic leukemia which developed from therpy\u2010related MDS with myelofibrosis","volume":"33","author":"Kondo H","year":"1992","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(11)80393-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205536"},{"key":"e_1_2_5_15_1","first-page":"122","article-title":"Megakaryoblastic termination of myeloproliferative disorders","volume":"40","author":"Amin MB","year":"1992","journal-title":"Henry Ford Hosp Med J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871201)60:11<2654::AID-CNCR2820601114>3.0.CO;2-Q"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01638.x"},{"key":"e_1_2_5_18_1","first-page":"243","article-title":"Chronic myelogenous leukemia terminating in acute megakaryoblastic leukemia. 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