{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:56:51Z","timestamp":1789505811902,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,4]]},"abstract":"The histologic characteristics of air space enlargement with fibrosis (AEF<\/jats:styled-content>) are compared with usual interstitial pneumonia (UIP<\/jats:styled-content>), nonspecific interstitial pneumonia (NSIP<\/jats:styled-content>) and centrilobular emphysema (CLE<\/jats:styled-content>) to determine similarities and differences. Lung specimens from 39 patients were studied; 9 with AEF<\/jats:styled-content>, 13 with UIP<\/jats:styled-content> and 5 with CLE<\/jats:styled-content> identified in lobectomy specimens for cancer and 12 NSIP<\/jats:styled-content> cases identified on surgical lung biopsies. We determined the characteristics of cystic structures (i.e. abnormal airspace), degree of inflammation and severity of pneumocyte injury semi\u2010quantitatively. In AEF<\/jats:styled-content>, the wall thickness of the cystic lesions (0.8\u2009mm) was thinner than in UIP<\/jats:styled-content> (2.1\u2009mm) and thicker than in CLE<\/jats:styled-content> (0.07\u2009mm). The degree of inflammation and granulation tissue were milder in AEF<\/jats:styled-content> than in UIP<\/jats:styled-content> and NSIP<\/jats:styled-content> and CLE<\/jats:styled-content> showed milder inflammatory cells than AEF<\/jats:styled-content>. As for pneumocyte injury, AEF<\/jats:styled-content> had fewer erosions (0.1\/case) and fewer ubiquitin\u2010positive pneumocytes than UIP<\/jats:styled-content> (4.8 cells\/slide) and NSIP<\/jats:styled-content> (9.8 cells\/slide). Our data suggested that the histological characteristics of AEF<\/jats:styled-content> differed significantly from UIP<\/jats:styled-content>, NSIP<\/jats:styled-content> and CLE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pin.12054","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T05:00:59Z","timestamp":1369112459000},"page":"206-213","source":"Crossref","is-referenced-by-count":38,"title":["Airspace enlargement with fibrosis shows characteristic histology and immunohistology different from usual interstitial pneumonia, nonspecific interstitial pneumonia and centrilobular emphysema"],"prefix":"10.1111","volume":"63","author":[{"given":"Tsutomu","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University Moroyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Uehara","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Mizutani","sequence":"additional","affiliation":[{"name":"University Research Center (Neurology) Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Saitama Cardiovascular and Respiratory Center Kumagaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Cardiovascular and Respiratory Center Kumagaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Cardiovascular and Respiratory Center Kumagaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602359"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201008-1274CI"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.11.1009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17101220"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03183.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/modpathol.3800671","article-title":"Respiratory bronchiolitis\u2010associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposal","volume":"9","author":"Yousem SA","year":"2006","journal-title":"Mod Pathol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.09.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03648.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007285"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02445.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03149.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4156"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_7_16_1","first-page":"182","article-title":"The definition of emphysema. 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