{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:20:28Z","timestamp":1697343628090},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Hepatocyte\u2010derived mutant amyloidogenic transthyretin (<jats:styled-content style=\"fixed-case\">ATTR<\/jats:styled-content>) causes familial amyloidotic polyneuropathy (<jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content>), for which orthotopic liver transplantation is an established curative treatment. However, some patients with <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> have cardiac amyloidosis after transplantation. Here, we describe a man with an autonomic disorder diagnosed as <jats:styled-content style=\"fixed-case\">FAP ATTR Val30Met<\/jats:styled-content> and marked cardiomegaly after liver transplantation. He underwent orthotopic liver transplantation at 49 years of age and was prescribed prednisolone to prevent graft rejection. Two years later, autonomic dysfunction and severe heart failure gradually developed. He died suddenly at 59. The autopsy revealed marked cardiomegaly (heart weight: 1020\u2009g). Histological and ultrastructural examinations demonstrated massive amyloid deposition and unusual myocardial hypertrophic injury associated with nuclear translocation of the glucocorticoid receptor (<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>). No other <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> patients without heart failure showed <jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content> nuclear translocation. <jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content> is a nuclear transcription factor that leads to myocardial hypertrophy, and cumulative prednisolone doses may promote marked cardiomegaly and severe cardiac amyloidosis.<\/jats:p>","DOI":"10.1111\/pin.12055","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T06:57:09Z","timestamp":1369810629000},"page":"260-265","source":"Crossref","is-referenced-by-count":1,"title":["Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study"],"prefix":"10.1111","volume":"63","author":[{"given":"Naomi","family":"Sakashita","sequence":"first","affiliation":[{"name":"Department of Cell Pathology Kumamoto University  Kumamoto Japan"},{"name":"Department of Human Pathology Institute of Health Bioscience The University of Tokushima Graduate School  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Institute of Health Bioscience The University of Tokushima Graduate School  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Kumamoto University  Kumamoto Japan"},{"name":"Undergraduate Student of School of Medicine Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Kumamoto University  Kumamoto Japan"},{"name":"Undergraduate Student of School of Medicine Kumamoto University  Kumamoto 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