{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:46:49Z","timestamp":1696247209519},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Metachronous bilateral renal cell carcinomas (<jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content>) are rare but well known. We present a case of metachronous bilateral <jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content> with a ureter orifice metastasis, for which the pathological diagnosis was confirmed with single nucleotide polymorphism microarray (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>) and gene expression assay (<jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content>). A 53\u2010year\u2010old man presented with a right ureteral obstruction. A cystoscopy showed a large pedunculated tumor emanating from the right ureteral orifice, consistent with a drop metastasis, which was biopsied. He had a history of a clear cell <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ccRCC<\/jats:styled-content>) 1.5 years prior and a right renal pelvic mass found 8 months later. Histologically, the biopsied right ureteral tumor demonstrated sheets of poorly differentiated cancer cells composed of a mixture of spindled and focal clear cell components. The main differential diagnosis was metastatic <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> versus urothelial carcinoma, but the immunohistochemical profile was not contributory. <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> revealed a genomic profile consistent with a metastatic <jats:styled-content style=\"fixed-case\">ccRCC<\/jats:styled-content> with loss of chromosome 3p. <jats:styled-content style=\"fixed-case\">GEA<\/jats:styled-content> showed a gene expression pattern consistent with kidney origin. The cytogenomic array also identified chromosome copy number patterns that were shared between both kidney tumors. This finding suggests that both tumors had a common origin, and thus, the metachronous <jats:styled-content style=\"fixed-case\">ccRCC<\/jats:styled-content> in the contralateral kidney represents a metastasis.<\/jats:p>","DOI":"10.1111\/pin.12068","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T09:05:14Z","timestamp":1371719114000},"page":"326-332","source":"Crossref","is-referenced-by-count":2,"title":["Cytogenomics and gene expression in a case of metachronous bilateral renal cell carcinomas with drop metastasis: Resolving a diagnostic dilemma with molecular technologies"],"prefix":"10.1111","volume":"63","author":[{"given":"Hidehiro","family":"Takei","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine The Methodist Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Barrios","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine The Methodist Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico A.","family":"Monzon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70151-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2008.10.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2008.10.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3181d527c5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/PDM.0b013e31815aca30","article-title":"Optimization of the Affymetrix GeneChip mapping 10K 2.0 assay for routine clinical use on formalin\u2010fixed paraffin\u2010embedded tissues","volume":"17","author":"Lyons\u2010Weiler M","year":"2008","journal-title":"Diagn Mol Pathol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/518809"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.06.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.04.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181a75e6d"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.88"},{"key":"e_1_2_5_12_1","first-page":"5999","article-title":"Identification from public data of molecular markers of adenocarcinoma characteristic of the site of origin","volume":"62","author":"Dennis JL","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_5_13_1","first-page":"7388","article-title":"Molecular classification of human carcinomas by use of gene expression signatures","volume":"61","author":"Su AI","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.2.216"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a2aa36"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0020041"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9570-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2010.02541.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.117.1.104"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64234-6"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:07:57Z","timestamp":1696205277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/pin.12068"],"URL":"https:\/\/doi.org\/10.1111\/pin.12068","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}