{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:59:26Z","timestamp":1788433166672,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Gastric adenocarcinoma of the fundic gland type (<jats:styled-content style=\"fixed-case\">GAFG<\/jats:styled-content>) and pyloric gland adenoma (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>) have recently been recognized as rare types of neoplasia. We performed comparative immunohistochemical and genetic analyses of 3 <jats:styled-content style=\"fixed-case\">GAFGs<\/jats:styled-content> and 12 <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content>. All of the 3 <jats:styled-content style=\"fixed-case\">GAFGs<\/jats:styled-content> were diffusely positive for pepsinogen\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>6, indicating the predominantly chief cell\/mucous neck cell differentiation of these tumors. A small number of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase\u2010positive parietal cells were also scattered. <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content> invariably exhibited diffuse <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>6 and <jats:styled-content style=\"fixed-case\">TFF<\/jats:styled-content>2 expression, consistent with the pyloric gland differentiation of these tumors. Ten of the 12 <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content> also unexpectedly exhibited focal expression of pepsinogen\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>1, suggesting that <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content> often show focal chief cell differentiation and phenotypically resemble mucous neck cells rather than pyloric glands. The mutation analyses revealed activating <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> mutations, which have been reported to be frequently detected in <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content>, in two of the <jats:styled-content style=\"fixed-case\">GAFGs<\/jats:styled-content>. While <jats:styled-content style=\"fixed-case\">GAFGs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content> are morphologically distinct lesions, our observations showed their partially overlapping immunohistochemical profiles and shared presence of <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> mutations, in addition to their common occurrence in the fundic gland mucosa. Based on these observations, we suggest that both <jats:styled-content style=\"fixed-case\">GAFGs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PGAs<\/jats:styled-content> are closely related lesions characterized by a mucous neck cell\/chief cell lineage phenotype.<\/jats:p>","DOI":"10.1111\/pin.12070","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T09:05:14Z","timestamp":1371719114000},"page":"318-325","source":"Crossref","is-referenced-by-count":61,"title":["Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma"],"prefix":"10.1111","volume":"63","author":[{"given":"Ryoji","family":"Kushima","sequence":"first","affiliation":[{"name":"Pathology and Clinical Laboratory Division National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology National Cancer Center Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Pathology and Clinical Laboratory Division National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Pathology and Clinical Laboratory Division National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Pathology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Pathology and Clinical Laboratory Division National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d94d53"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825033e7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817d7ff4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-006-0381-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-002-0750-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4153"},{"key":"e_1_2_6_8_1","first-page":"85","volume-title":"Biopsy Interpretation of the Gastrointestinal Tract Mucosa. 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