{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:29:17Z","timestamp":1790688557634,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>A 63\u2010year\u2010old <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese man complained of lower back pain and numbness and was diagnosed as intradural tumors at the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>11\/12 and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>1 level. The thoracic tumor originated from the posterior nerve root, and the lumbar tumor originated from the cauda equina. Five months after surgical resection, the patient developed recurrent tumor consisting of enlargement of multiple caudal nerves. Pathologically, the primary tumors showed a nodular and lobular pattern, including spindle cells in a fascicular, whorl and storiform pattern, with variable cellularity, nuclear palisading and frequent small onion bulb structures. Mild pleomorphism was present, and there were four mitoses per 10 high power fields. Many cells showed immunoreactivity for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010100 and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ox10. There were also claudin\u20101\u2010positive spindle cells, but no epithelial membrane antigen (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>)\u2010positive cells. The cells in onion bulb structures were positive for claudin\u20101 and glucose transporter 1 (<jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101). These findings led to a diagnosis of hybrid schwannoma\/perineurioma. The features of high cellularity, pleomorphism and a <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 index over 10% suggested a low\u2010malignant nature. The recurrent tumor also showed high proliferative activity, as reflected by mitotic figures and a <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 index of 20%. This is the first case of spinal nerve hybrid schwannoma\/perineurioma with low malignant potential and peculiar intraneural perineurioma component.<\/jats:p>","DOI":"10.1111\/pin.12073","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T04:47:32Z","timestamp":1374209252000},"page":"368-373","source":"Crossref","is-referenced-by-count":15,"title":["Hybrid schwannoma\/perineurioma of the spinal nerve: Multifocal occurrence, and recurrence as an intraneural perineurioma"],"prefix":"10.1111","volume":"63","author":[{"given":"Tomayoshi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Pathology Nagasaki University Hospital  Nagasaki Japan"},{"name":"Nagasaki Diagnostic Pathology Clinic  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukimasa","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Nishimura Clinic  Shimabara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Nagasaki Diagnostic Pathology Clinic  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"e_1_2_5_2_1","series-title":"Tumors of the Peripheral Nervous System","volume-title":"Atlas of Tumor Pathology","author":"Scheithauer BW","year":"1999"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181658c14"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200212000-00010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000062654.83617.B7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687045"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00419.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1102-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181accc6c"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2004.12.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-008-0418-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.6.696"},{"key":"e_1_2_5_13_1","first-page":"825","article-title":"Malignant transformation in a hybrid schwannoma\/perineurioma: Addition to the spectrum of a malignant peripheral nerve sheath tumor","volume":"54","author":"Rekhi B","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155166.86409.d2"},{"key":"e_1_2_5_15_1","first-page":"241","volume-title":"Histology for Pathologists","author":"Ortiz\u2010Hidalgo C","year":"2007"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31816f8519"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12073","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:21:12Z","timestamp":1696209672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/pin.12073"],"URL":"https:\/\/doi.org\/10.1111\/pin.12073","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}