{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:40:53Z","timestamp":1771476053261,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Metastasizing pleomorphic adenoma (<jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>) is the inexplicable metastasis of a histologically benign pleomorphic adenoma (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>). Approximately 50 cases have been reported. A 62\u2010year\u2010old woman noticed pain in the upper molar area. Her medical history included an operation for <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> in the hard palate that was performed 20 years previously. On imaging, four relatively well\u2010defined lesions were demonstrated in the maxillary bone. She underwent an operation for these lesions. Each lesion revealed the same histological features. Morphological findings displayed typical features of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>. Immunohistochemical staining showed that tumor cells of both primary and metastasizing lesions were positive for pleomorphic adenoma gene (<jats:styled-content style=\"fixed-case\">PLAG<\/jats:styled-content>) 1, which is a sensitive marker for <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>. Gene fusions involving <jats:styled-content style=\"fixed-case\">PLAG1<\/jats:styled-content> were examined by reverse transcription\u2010polymerase chain reaction. However, no gene rearrangements of <jats:styled-content style=\"fixed-case\">PLAG1<\/jats:styled-content> were found. We report here on a case of <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> in the maxillary bone, which appeared 20 years after resection of the primary tumor and review the relevant literature.<\/jats:p>","DOI":"10.1111\/pin.12087","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T05:54:37Z","timestamp":1377669277000},"page":"463-468","source":"Crossref","is-referenced-by-count":20,"title":["A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate"],"prefix":"10.1111","volume":"63","author":[{"given":"Jun","family":"Akiba","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Seichokai Fuchu 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