{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:00:46Z","timestamp":1787500846839,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"crossref","award":["10-24213"],"award-info":[{"award-number":["10-24213"]}],"id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Labor and Welfare of Japan"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MEXT Special Coordination Funds for Promoting Science and Technology Grant"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science Fellows","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"\n Multiwalled carbon nanotubes (\n MWCNTs<\/jats:styled-content>\n ) have attracted public attention not only for their potential applications in engineering and materials science but also for possible environmental risks.\n MWCNTs<\/jats:styled-content>\n share similar properties with asbestos, a definite human carcinogen causing malignant mesothelioma (\n MM<\/jats:styled-content>\n ), in that they are both biopersistent thin fibers with a high aspect ratio. Certain types of\n MWCNTs<\/jats:styled-content>\n do induce\n MM<\/jats:styled-content>\n in animal experiments. Though there are many different types of\n MWCNTs<\/jats:styled-content>\n awaiting use in industry, there is little evidence about what types of\n MWCNTs<\/jats:styled-content>\n present a high risk for\n MM<\/jats:styled-content>\n \u2005\n in vivo<\/jats:italic>\n . We have previously shown that the diameter of\n MWCNTs<\/jats:styled-content>\n is one of the critical factors for mesothelial injury, which eventually leads to\n MM<\/jats:styled-content>\n . Because of the extensive commercial use of\n MWCNTs<\/jats:styled-content>\n , the properties of\n MWCNTs<\/jats:styled-content>\n that determine carcinogenic activity should be clarified. Here we report that a high dose (10\u2009mg) of a tangled form of pristine\n MWCNT<\/jats:styled-content>\n (with a diameter of 15\u2009nm) did not induce\n MM<\/jats:styled-content>\n after intraperitoneal administration in rats, which were followed for up to 3 years after injection. This observation strengthens our previous finding that the rigidity, diameter, length and surface properties of\n MWCNTs<\/jats:styled-content>\n are important factors in\n MM<\/jats:styled-content>\n induction\n in vivo<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/pin.12093","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T18:19:45Z","timestamp":1444760385000},"page":"457-462","source":"Crossref","is-referenced-by-count":48,"title":["Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15\u2009nm in diameter does not induce mesothelial carcinogenesis in rats"],"prefix":"10.1111","volume":"63","author":[{"given":"Hirotaka","family":"Nagai","sequence":"first","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan Hwu","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumitsu","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute for Advanced Research Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute for Advanced Research Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Toyokuni","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cen-v085n046.p029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.241"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.06.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0708-774"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.327"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.05.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-7-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.105"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.34.65"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp100"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02326.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110013108"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4075"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.140"},{"key":"e_1_2_6_16_1","first-page":"w13547","article-title":"Inhaled nanoparticles and lung cancer\u2014what we can learn from conventional particle toxicology","volume":"142","author":"Donaldson K","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.1.B54"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Mechanisms of asbestos\u2010induced carcinogenesis","volume":"71","author":"Toyokuni S","year":"2009","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.03.023"}],"container-title":["Pathology 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