{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:48:18Z","timestamp":1696225698592},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Chromophobe renal cell carcinoma (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) accounts for approximately 5% of renal epithelial neoplasms. Multiple and\/or bilateral chromophobe <jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content> in an individual are generally rare but frequently occur in patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>irt\u2013<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ogg\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ub\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">BHDS<\/jats:styled-content>) and in patients with tuberous sclerosis complex (<jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content>). The responsible genes in both <jats:styled-content style=\"fixed-case\">BHDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TSC<\/jats:styled-content> act as tumor suppressors. Therefore, it seems that some genetic backgrounds are required for the generation and progression of multiple chromophobe <jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content>. Here, we report a case of multiple and bilateral chromophobe <jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content> along with several small\u2010sized capsular angiomyolipomas known as \u2018capsulomas\u2019 in a 39\u2010year\u2010old woman who had neither a particular medical history nor specific gene mutation. There has been no report of sporadic multiple chromophobe <jats:styled-content style=\"fixed-case\">RCCs<\/jats:styled-content> and \u2018capsulomas\u2019 developing in a patient without genetic features, having potential for novel genetic variation.<\/jats:p>","DOI":"10.1111\/pin.12099","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T10:45:32Z","timestamp":1382093132000},"page":"510-515","source":"Crossref","is-referenced-by-count":0,"title":["Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with \u2018capsulomas\u2019 without <i><scp>FCLN<\/scp><\/i> gene abnormality"],"prefix":"10.1111","volume":"63","author":[{"given":"Kotaro","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takasawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ichimiya","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Surgery Sapporo Tsukisamu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan J.P.","family":"Gille","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics VU University Medical Center  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Pathology Kochi Red Cross Hospital  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimasa","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711550402"},{"key":"e_1_2_6_3_1","first-page":"356","article-title":"Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization","volume":"145","author":"Speicher MR","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.463"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04727.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000058253.40352.60"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-012-9593-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.4.539"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.1363e.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00413-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02095.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603781103"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1997.tb00147.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200212000-00002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.05.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.02.053"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi444"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205838200"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02945.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02039.x"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:00:14Z","timestamp":1696165214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/pin.12099"],"URL":"https:\/\/doi.org\/10.1111\/pin.12099","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}