{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:55:24Z","timestamp":1790229324795,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>There is no consensus as to whether or not metastatic nodules in the liver should be biopsied for tumor grading in cases of neuroendocrine tumors with \u2018synchronous liver metastasis\u2019. In this study, we compared the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 labeling index between the primary tumor and synchronous liver metastasis in 30 patients, who had received simultaneous resections. Examined tumors were of the small bowel (n = 18) or pancreas (n = 12), and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 or <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2 in primary histologic grade. In 20 patients (67%), the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 index was similar between the primary tumor and liver metastasis, but 10 (33%) showed an elevation of 3.4\u201314.4% in the liver, which increased the tumor grade in 4 cases. The <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 elevation in the liver was more common in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2 than <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 neoplasms (<jats:italic>P<\/jats:italic> = 0.002). The size, but not number, of liver metastases was significantly larger in patients with an elevated <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 index (<jats:italic>P<\/jats:italic> = 0.006). Using 40\u2009mm as a provisional cutoff for the greatest diameter of liver metastases, the positive predictive value of this discriminator for elevated <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 was 56%, and the negative predictive value was 93%. In conclusion, synchronous liver metastases can yield a higher <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 labeling index than primary neuroendocrine tumours, particularly when the secondary is greater than 40\u2009mm.<\/jats:p>","DOI":"10.1111\/pin.12108","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T09:37:24Z","timestamp":1385458644000},"page":"532-538","source":"Crossref","is-referenced-by-count":27,"title":["Elevated <scp>K<\/scp>i\u201067 labeling index in \u2018synchronous liver metastases\u2019 of well differentiated enteropancreatic neuroendocrine tumor"],"prefix":"10.1111","volume":"63","author":[{"given":"Yoh","family":"Zen","sequence":"first","affiliation":[{"name":"Histopathology Section King's College London School of Medicine at King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Heaton","sequence":"additional","affiliation":[{"name":"Division of Liver Transplantation and HPB Surgery Institute of Liver Studies King's College London School of Medicine at King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970215)79:4<813::AID-CNCR19>3.0.CO;2-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0734"},{"key":"e_1_2_5_4_1","volume-title":"AJCC Cancer Staging Manual","author":"Edge SB","year":"2009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0924-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300831"},{"key":"e_1_2_5_7_1","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman FT","year":"2010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0250-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318272ff77"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.06.011"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90303-2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318263207c"},{"key":"e_1_2_5_13_1","first-page":"441A","article-title":"Comparative analysis of different counting methodologies for Ki\u201067 in pancreatic neuroendocrine tumors","volume":"25","author":"Bagci P","year":"2012","journal-title":"Mod Pathol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821a0696"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.177"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2462-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213309.51553.01"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02662.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ac675b"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181da0a20"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2461-9"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:38:01Z","timestamp":1695976681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/pin.12108"],"URL":"https:\/\/doi.org\/10.1111\/pin.12108","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}