{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:22:37Z","timestamp":1761765757031},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Development of secondary neoplasm in mature teratomas is a long\u2010term potential risk in growing teratoma syndrome (<jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content>) of the ovary. The origin or histogenesis of the secondary neoplasm, however, is scarcely understood. We herein report two cases of <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content> that began secondary neoplastic change 10 and 22 years after initial presentation. In one case, microscopic carcinoids were scattered over various mature elements derived from three germ cell layers: some were close to the intestinal\u2010type glands or adipose tissue and others lay in the glia. This implies that these carcinoids multicentrically originated from pluripotent stem cells that had been latent in various mature tissues. In contrast, the other case had only one focus of intestinal\u2010type tubular adenocarcinoma, measuring 5\u2009mm in diameter, adjacent to the intestinal\u2010type glands. Malignant transformation of intestinal\u2010type glands is most likely to account for this adenocarcinoma. In both cases, peritoneal mature teratomas also contained foci of endometriosis, almost exclusively in their glial components. In conclusion, the present cases suggest two diverse histogenesis of secondary neoplasm in <jats:styled-content style=\"fixed-case\">GTS<\/jats:styled-content> and a specific role of glia in the development of endometriosis in peritoneal teratomas.<\/jats:p>","DOI":"10.1111\/pin.12112","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:57:39Z","timestamp":1389769059000},"page":"607-610","source":"Crossref","is-referenced-by-count":11,"title":["How does secondary neoplasm arise from mature teratomas in growing teratoma syndrome of the ovary? A report of two cases"],"prefix":"10.1111","volume":"63","author":[{"given":"Noriko","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Pathology Tsuruoka Municipal Shonai Hospital  Tsuruoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Uchigasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Tsuruoka Municipal Shonai Hospital  Tsuruoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Fukase","sequence":"additional","affiliation":[{"name":"Department of Pathology Tsuruoka Municipal Shonai Hospital  Tsuruoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1629::AID-CNCR2820500828>3.0.CO;2-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000231686.94924.41"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318073cf44"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000273205"},{"key":"e_1_2_6_6_1","first-page":"267","volume-title":"Atlas of Tumor Pathology. 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