{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:42:45Z","timestamp":1759333365799},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Isolated peripheral neutrophils spontaneously underwent apoptosis in association with extra\u2010cellular liberation of the monocyte\u2010attracting ribosomal protein <jats:styled-content style=\"fixed-case\">S19<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content>) oligomers. This apoptosis was prevented by the simultaneous presence of anti\u2010<jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> antibodies or of a <jats:styled-content style=\"fixed-case\">C5a<\/jats:styled-content> receptor antagonist, but was promoted by supplementing extrinsic <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> oligomers. Transformed <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>\u201060 cells to over\u2010produce <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln137<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sn\u2010mutant <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> were differentiated to neutrophil\u2010like cells. The neutrophil\u2010like cells gained resistance against the spontaneous apoptosis concomitant with the generation of non\u2010functional <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> oligomers. When the neutrophil\u2010like cells were intradermally transplanted into mice, the mutant <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content>\u2010producing neutrophils persisted for a long period of time, whereas wild\u2010type <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content>\u2010producing neutrophils underwent apoptosis and were promptly cleared by infiltrated macrophages. When an experimental pleurisy was introduced by injecting carrageenan into the pleural cavity of mice, the inflammation spread slightly to lung parenchyma. When antibodies neutralizing the <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> oligomers were simultaneously administrated with carrageenan, the neutrophil infiltration in the lung parenchymal lesion become more severe, occurring as alveolar septal destruction and hemorrhage concomitant with an augmented neutrophil number in the pleural exudate. These results indicate the importance of the <jats:styled-content style=\"fixed-case\">RP S19<\/jats:styled-content> oligomers and the <jats:styled-content style=\"fixed-case\">C5a<\/jats:styled-content> receptor in neutrophil clearance and acute inflammation resolution.<\/jats:p>","DOI":"10.1111\/pin.12115","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:57:39Z","timestamp":1389769059000},"page":"581-590","source":"Crossref","is-referenced-by-count":9,"title":["Involvement of regional neutrophil apoptosis promotion by ribosomal protein <scp>S<\/scp>19 oligomers in resolution of experimental acute inflammation"],"prefix":"10.1111","volume":"63","author":[{"given":"Hiroshi","family":"Nishiura","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Faculty of Life Science Kumamoto University  Kumamoto 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