{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:29:52Z","timestamp":1766269792415},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Cystic adventitial disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) is a rare peripheral artery disorder which shows the development of gelatinous cysts in the adventitia. Although several theories for the pathogenesis of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> have been postulated, the etiology of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> remains unclear. Histological examination of three <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> cases revealed that these cyst walls were composed of fibrous tissue and lacked both epithelial and endothelial lining. The surfaces of these cysts were partially covered with spindle\u2010shaped cells, similar to the interstitial cells within the cyst wall. A pool of mucinous material in the adventitia was evident. Distribution of vimentin\u2010positive spindle\u2010shaped cells and scattered <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68\u2010positive oval\u2010shaped cells in the cyst wall was revealed by immunohistochemistry. A part of vimentin\u2010positive spindle\u2010shaped cells demonstrated to be positive for \u03b1\u2010smooth muscle actin, indicating the presence of myofibroblasts in the cyst wall. A focal tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010positive area was observed in the cyst wall of our <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> cases. Presence of two different cell types, proliferation of myofibroblasts and expression of tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> were consistent with those of cyst walls of 20 surgically resected ganglions. These results suggest that <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> may arise as capsular synovial structures, similar to ganglion cysts.<\/jats:p>","DOI":"10.1111\/pin.12119","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:57:39Z","timestamp":1389769059000},"page":"591-598","source":"Crossref","is-referenced-by-count":9,"title":["Distribution of myofibroblast and tenascin\u2010<scp>C<\/scp> in cystic adventitial disease: Comparison with ganglion"],"prefix":"10.1111","volume":"63","author":[{"given":"Hiroyuki","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsue","family":"Ishibashi\u2010Ueda","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitane","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Police Hospital  Osaka City Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197902000-00007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70155-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-003-2676-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.06.117"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03625.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600523"},{"key":"e_1_2_6_8_1","first-page":"573","article-title":"Cystic adventitial disease of the popliteal artery. 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