{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:25:07Z","timestamp":1768458307262,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Gastrointestinal stromal tumors (<jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s) are the most common mesenchymal neoplasms of the gastrointestinal tract, and typically present as discrete well\u2010circumscribed but non\u2010encapsulated tumor masses. In this report, we describe a case of colonic perforation caused by an unusual form of <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>. A 72\u2010year\u2010old <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese woman presented to the emergency department with acute abdominal pain. Under the provisional diagnosis of sigmoid colon perforation, a laparoscopic sigmoidectomy was performed. Although the tumor mass was undetectable during the preoperative examination, a spindle cell lesion with a diffuse longitudinal growth pattern replacing the muscularis propria was revealed by microscopic examination. The spindle cell lesion was exposed at the perforation, suggesting a causal relationship between the lesion and the perforation. The spindle cell lesion was <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>\u2010positive and had a mutation in the <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> gene at exon 11. We diagnosed it as diffuse infiltrating <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>. We consider that the lesion would be a cause of the colonic perforation, and emphasize the importance of accurate diagnosis of the lesion by histological, immunohistochemical and genetic examinations.<\/jats:p>","DOI":"10.1111\/pin.12124","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:47:07Z","timestamp":1390992427000},"page":"34-38","source":"Crossref","is-referenced-by-count":10,"title":["A case of diffuse infiltrating gastrointestinal stromal tumor of sigmoid colon with perforation"],"prefix":"10.1111","volume":"64","author":[{"given":"Daisuke","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Usami","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Kobe Japan"},{"name":"Clinical Laboratory Osaka University Dental Hospital  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Toyosawa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Osaka University Graduate School of Dentistry  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000338"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03812.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/00015458.2006.11679875","article-title":"A ruptured gastrointestinal stromal tumor of the transverse mesocolon: A case report","volume":"106","author":"Jacobs K","year":"2006","journal-title":"Acta Chir Belg"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-010-4434-6"},{"key":"e_1_2_6_6_1","first-page":"297","article-title":"Perforated GIST of the small intestine as a rare cause of acute abdomen: Surgical treatment and adjuvant therapy. Case report","volume":"15","author":"Efremidou EI","year":"2006","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157938.95785.da"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1487"},{"key":"e_1_2_6_9_1","first-page":"549","article-title":"Sporadic segmental Interstitial cell of cajal hyperplasia (microscopic GIST) with unusual diffuse longitudinal growth replacing the muscularis propria: Differential diagnosis to hereditary GIST syndromes","volume":"3","author":"Agaimy A","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701716490"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-2-24"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.031"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:03:50Z","timestamp":1696032230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/pin.12124"],"URL":"https:\/\/doi.org\/10.1111\/pin.12124","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}