{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:34:35Z","timestamp":1785000875545,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>It has been speculated that intraductal dissemination, via the pancreatic duct, bile duct, or mammary duct, is a unique form of cancer cell spread. However, clinical evidence to confirm this form of dissemination has been lacking. Here we report a case of papillary adenocarcinoma of the ampulla of <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ater in which retrograde dissemination to the pancreatic duct was strongly suggested. A 79\u2010year\u2010old woman underwent pancreatoduodenectomy for a 22\u2009mm microinvasive papillary adenocarcinoma of the ampulla. Multiple carcinomas <jats:italic>in situ<\/jats:italic> were found in the pancreatic duct distant from the ampulla. Seven months later, she underwent a second operation for a recurrent papillary adenocarcinoma at the pancreato\u2010jejunal anastomosis showing exophytic and expansive growth into the jejunal lumen that connected to an intraductal adenocarcinoma in the pancreatic body. None of these tumors showed invasive growth, or vascular or neural invasion, being separate from each other but sharing identical histological, immunohistochemical, and molecular features; papillary growth, a pancreatobiliary phenotype, the same pattern of genomic loss of heterozygosity, and no mutation of the <jats:italic><jats:styled-content style=\"fixed-case\">KRAS<\/jats:styled-content><\/jats:italic>, <jats:italic><jats:styled-content style=\"fixed-case\">TP53<\/jats:styled-content><\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> genes. These results imply that this papillary adenocarcinoma of the ampulla of <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ater had disseminated to the pancreatic duct in a retrograde manner and recurred in the remnant pancreas.<\/jats:p>","DOI":"10.1111\/pin.12131","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:47:07Z","timestamp":1390992427000},"page":"39-44","source":"Crossref","is-referenced-by-count":7,"title":["Intraductal dissemination of papillary adenocarcinoma of the ampulla of <scp>V<\/scp>ater in the pancreatic duct"],"prefix":"10.1111","volume":"64","author":[{"given":"Akiko","family":"Matsubara","sequence":"first","affiliation":[{"name":"Division of Molecular Pathology National Cancer Center Research Institute  Tokyo Japan"},{"name":"Pathology and Clinical Laboratories National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nara","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Pancreatic Surgery Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Sekine","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ojima","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Kosuge","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Pancreatic Surgery Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Pancreatic Surgery Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Kushima","sequence":"additional","affiliation":[{"name":"Pathology and Clinical Laboratories National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yae","family":"Kanai","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e2bc11"},{"key":"e_1_2_6_3_1","first-page":"87","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Albores\u2010Saavedra J","year":"2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.19797"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF02781767","article-title":"Experimental study of transductal dissemination of cancer of the pancreas","volume":"12","author":"Fujita N","year":"1977","journal-title":"Gastroenterol Jpn"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850515)55:10<2459::AID-CNCR2820551025>3.0.CO;2-L"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0315"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0917-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181723679"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1997.tb00460.x"},{"key":"e_1_2_6_13_1","first-page":"1163","article-title":"Neoplasia of the ampulla of Vater. Ki\u2010ras and p53 mutations","volume":"142","author":"Scarpa A","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f8ff05"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00161"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002543"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12131","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:03:52Z","timestamp":1696032232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/pin.12131"],"URL":"https:\/\/doi.org\/10.1111\/pin.12131","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}