{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:02:30Z","timestamp":1758704550975},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Although immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related diseases (<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) have been found to affect many organs, little is known about their effects on the colonic mucosae. Pathological examination of colon adenomas has shown inflammatory cell infiltration into the stroma. We therefore assessed the clinicopathological characteristics of colon adenomas in patients with type 1 autoimmune pancreatitis (<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>\u20101), a representative <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. Both colon adenomas from patients with (<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas) and without (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>on\u2010<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas) <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> were characterized by moderate to severe lymphoplasmacytic and eosinophilic inflammation without fibrosis or phlebitis. The ratio of <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010positive to <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>\u2010positive plasma cells (<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\/<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> ratio) and the numbers of <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010positive plasma cells were significantly higher in <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas than in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>on\u2010<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas. <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010positive plasma cells tended to be distributed diffusely in lower areas of the mucosae in <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas. We were unable to confirm whether <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas constituted an <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas in the setting of <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> may provide useful pathological information, supplementing a diagnosis of <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> outside the colon, or may facilitate examination for <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>, especially <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>\u20101. <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>4 adenomas warrant further investigation.<\/jats:p>","DOI":"10.1111\/pin.12139","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T11:21:58Z","timestamp":1394796118000},"page":"67-74","source":"Crossref","is-referenced-by-count":3,"title":["Inflammation of colon adenoma in the setting of type 1 autoimmune pancreatitis"],"prefix":"10.1111","volume":"64","author":[{"given":"Takeshi","family":"Uehara","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Hamano","sequence":"additional","affiliation":[{"name":"Division of Medical Informatics Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Suga","sequence":"additional","affiliation":[{"name":"Gastroenterology, Department of Medicine Shinshu University School of Medicine  Matsumoto 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