{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:10Z","timestamp":1787015950997,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    Adenosquamous carcinoma (\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    ) is a rare malignant neoplasm of the head and neck regions. We elucidated the relationship between\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    molecule expression. We selected 14 cases of\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    in the head and neck, and examined them immunohistohcmically. Seven cases of tongue, 3 cases of larynx and 4 cases of hypopharynx carcinoma were selected. Nine (64.3%) of 14 cases showed lymph node metastasis at the diagnosis. Laryngeal and hypopharyngeal cases showed a higher stage. Six cases (66.7%), all of which showed lymph node metastases, died of disease. Immunohistochemical examinations showed that\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    was positive for both markers of squamous cell carcinoma and adenocarcinoma.\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    showed positivity for\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    1 (13 cases: 92.3%),\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    1core (12 cases: 85.2%) and\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    4 (12 cases: 85.7%). In rare\n                    <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\n                    of the head and neck region, it was revealed that\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    1 and\n                    <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>\n                    4 expression might be associated with its nodal status.\n                  <\/jats:p>","DOI":"10.1111\/pin.12144","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T04:28:50Z","timestamp":1396585730000},"page":"104-114","source":"Crossref","is-referenced-by-count":14,"title":["<scp>MUC<\/scp>\n                    expression in adenosquamous carcinoma of the head and neck regions of\n                    <scp>J<\/scp>\n                    apanese patients: Immunohistochemical analysis"],"prefix":"10.1111","volume":"64","author":[{"given":"Kimihide","family":"Kusafuka","sequence":"first","affiliation":[{"name":"Pathology Division Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Pathology Division Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Iida","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Mori","sequence":"additional","affiliation":[{"name":"Clinical Trial Coordination Office Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miki","sequence":"additional","affiliation":[{"name":"Pathology Division Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihito","family":"Suda","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Fuke","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Onitsuka","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Pathology Division Shizuoka Cancer Center  Sunto\u2010gun Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"130","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours","author":"Cardesa A","year":"2005"},{"key":"e_1_2_6_3_1","first-page":"368","volume-title":"Tumors of the Salivary Glands. 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