{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:43:18Z","timestamp":1768873398057,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,3]]},"abstract":"CD<\/jats:styled-content>5\u2010positive follicular lymphoma (FL<\/jats:styled-content>), although rare, has been described in a number of case reports. However, a statistically valid, clinicopathological comparison between CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content> and CD<\/jats:styled-content>5\u2010negative FL<\/jats:styled-content> has never been performed because of its rarity. We statistically compared clinicopathological characteristics of 22 cases of CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content>, diagnosed by immunohistochemistry, flow cytometry and morphological findings, with those of 62 cases of FL<\/jats:styled-content> without CD<\/jats:styled-content>5 expression (control cases). CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content> patients showed a higher tendency of peripheral blood involvement (P<\/jats:italic> = 0.076) and a higher frequency of CD<\/jats:styled-content>25 expression (P<\/jats:italic> = 0.0004) and MUM<\/jats:styled-content>1 protein expression (P<\/jats:italic> = 0.0008), and a lower frequency of t(14;18)(q32;q21) (P<\/jats:italic> = 0.017). The overall survival (OS<\/jats:styled-content>) curve of CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content> was significantly worse than that of control cases (P<\/jats:italic> = 0.0266), although progression\u2010free survival curves did not show a significant difference (P<\/jats:italic> = 0.7899). Moreover, CD<\/jats:styled-content>5 expression was shown to be an independent poor prognostic factor for OS<\/jats:styled-content> in both univariate analysis [H<\/jats:styled-content>azard R<\/jats:styled-content>atio (HR<\/jats:styled-content>), 3.63; P<\/jats:italic> = 0.0464] and multivariate analysis (HR<\/jats:styled-content>, 57.16; P<\/jats:italic> = 0.0001). CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content> showed different clinicopathological characteristics from FL<\/jats:styled-content> lacking CD<\/jats:styled-content>5 expression. These results suggest that CD<\/jats:styled-content>5\u2010positive FL<\/jats:styled-content> should be considered a different type of FL<\/jats:styled-content>, and its clinicopathological management should be conducted differently.<\/jats:p>","DOI":"10.1111\/pin.12145","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T08:28:50Z","timestamp":1396600130000},"page":"95-103","source":"Crossref","is-referenced-by-count":20,"title":["CD<\/scp>5\u2010positive follicular lymphoma characterized by CD<\/scp>25, MUM<\/scp>1, low frequency of t(14;18) and poor prognosis"],"prefix":"10.1111","volume":"64","author":[{"given":"Hiroaki","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Sato","sequence":"additional","affiliation":[{"name":"Biostatistics Center School of Medicine Kurume University Kurume 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