{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:17:55Z","timestamp":1779193075160,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Adenomyosis is characterized by extension of endometrial glands and stromal cells into the myometrium. Here we proved that \u2018moesin\u2019 is a unique biomarker of adenomyosis. We selected two cases of adenomyosis that had been surgically resected and fixed with formalin. Proteins were extracted from the infiltrating adenomyosis lesions and normal endometrium by tissue microdissection. The extracted proteins were examined using a <jats:styled-content style=\"fixed-case\">LC\u2010MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> system and the expression profiles of each region were compared. Two hundred and sixty proteins were detected, among which 73 were expressed more in adenomyosis than in normal endometrium. Among these proteins, we focused on overexpression of moesin in adenomyosis. Expression of moesin estimated semiquantitatively using an immunohistochemistry score was higher in adenomyosis than in normal endometrium. In particular, moesin was significanly overexpressed in stromal cells of adenomyosis than in those of normal endometrium. Relative to normal endometrium, moesin was also overexpressed at the <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level in 9 of 14 cases of adenomyosis and at the protein level in all 14 cases. We also detected activated (phosphorylated) moesin in adenomyosis lesions. The present findings suggest that moesin is characteristically overexpressed and activated in adenomyosis, and that moesin activation may be related to extension of adenomyosis in the myometrium.<\/jats:p>","DOI":"10.1111\/pin.12148","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T08:28:50Z","timestamp":1396600130000},"page":"115-122","source":"Crossref","is-referenced-by-count":8,"title":["Moesin overexpression is a unique biomarker of adenomyosis"],"prefix":"10.1111","volume":"64","author":[{"given":"Rena","family":"Ohara","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Michikami","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaishi","family":"Satomi","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Shiba\u2010Ishii","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, University of Tsukuba  Tsukuba\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del493"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61733-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.090"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2761"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.131"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.72.137"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800675"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196111\/12)14:6<1166::AID-CNCR2820140605>3.0.CO;2-J"},{"key":"e_1_2_5_10_1","first-page":"849","article-title":"Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two\u2010dimensional electrophoresis and liquid chromatography\u2010mass spectrometry\/mass spectrometry","volume":"30","author":"Mikuriya K","year":"2007","journal-title":"Int J Oncol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.053157"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002238"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00772.x"},{"key":"e_1_2_5_14_1","first-page":"608","article-title":"Proteomic analysis reveals overexpression of moesin and cytokeratin 17 proteins in colorectal carcinoma","volume":"27","author":"Kim CY","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1323-03"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.01.017"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(98)70122-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-4900(00)01078-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02255.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12202"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.056523"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04204.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-02-0119"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml045"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.075226"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:53:11Z","timestamp":1696171991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/pin.12148"],"URL":"https:\/\/doi.org\/10.1111\/pin.12148","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}