{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:48:56Z","timestamp":1756075736075},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Endometrial stromal tumors (<jats:styled-content style=\"fixed-case\">ESTs<\/jats:styled-content>) are composed of cells resembling endometrial stroma, and are divided into benign and malignant types based on morphology. Endometrial stromal nodule (<jats:styled-content style=\"fixed-case\">ESN<\/jats:styled-content>) is a benign localized tumor, and endometrial stromal sarcoma (<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>) is an infiltrative and potentially metastatic neoplasm. A series of genetic aberrations contribute to pathological diagnosis of <jats:styled-content style=\"fixed-case\">ESTs<\/jats:styled-content>. At present, subsets of <jats:styled-content style=\"fixed-case\">ESN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>\u2010low grade (<jats:styled-content style=\"fixed-case\">ESS\u2010LG<\/jats:styled-content>) are characterized as <jats:italic><jats:styled-content style=\"fixed-case\">JAZF<\/jats:styled-content>1\u2010<jats:styled-content style=\"fixed-case\">SUZ<\/jats:styled-content>12\/<jats:styled-content style=\"fixed-case\">JJAZ<\/jats:styled-content>1<\/jats:italic> gene fusion. The <jats:styled-content style=\"fixed-case\">ESTs<\/jats:styled-content> that show higher grade atypia but lack nuclear pleomorphism include <jats:italic><jats:styled-content style=\"fixed-case\">YWHAE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FAM<\/jats:styled-content>22<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>. Here we report an unusual case of <jats:styled-content style=\"fixed-case\">ESTs<\/jats:styled-content>. Sudden colonic perforation occurred to the patient, and emergency surgery was performed. Pathological findings suggested metastatic <jats:styled-content style=\"fixed-case\">ESS<\/jats:styled-content>. Thorough medical examination of the genital organs detected a 1\u2009cm\u2010sized well\u2010demarcated uterine tumor. Microscopically, the tumor lacked infiltrative features, conforming to the definition of <jats:styled-content style=\"fixed-case\">ESN<\/jats:styled-content>. Both lesions demonstrated identical cytology and shared <jats:italic><jats:styled-content style=\"fixed-case\">JAZF<\/jats:styled-content>1\u2010<jats:styled-content style=\"fixed-case\">SUZ<\/jats:styled-content>12<\/jats:italic> gene fusion<jats:italic>.<\/jats:italic> Endometriosis was not found in any areas of the resected organs, strongly suggesting that the uterine orthotopic tumor metastasized. The current case uncovered the problems of differential diagnosis between <jats:styled-content style=\"fixed-case\">ESN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESS\u2010LG<\/jats:styled-content>. We demonstrate detailed pathological features of the two lesions, and discuss the possibility of orthotopic <jats:styled-content style=\"fixed-case\">EST<\/jats:styled-content> with limited infiltration to develop into <jats:styled-content style=\"fixed-case\">ESS\u2010LG<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pin.12151","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T04:11:26Z","timestamp":1398053486000},"page":"178-182","source":"Crossref","is-referenced-by-count":5,"title":["Colonic low\u2010grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the <scp>JAZF<\/scp>1\u2010<scp>SUZ<\/scp>12 gene fusion"],"prefix":"10.1111","volume":"64","author":[{"given":"Aya","family":"Tokinaga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"},{"name":"Department of Pathology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Niino","sequence":"additional","affiliation":[{"name":"Departments of  Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Udaka","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Asai\u2010Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sekido","sequence":"additional","affiliation":[{"name":"Surgery National Hospital Organization Yokohama Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213327.86992.d1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.12.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816a3b42"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824a7b1a"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.162"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.anndiagpath.2004.10.009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60568-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3985"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T02:56:22Z","timestamp":1696215382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/pin.12151"],"URL":"https:\/\/doi.org\/10.1111\/pin.12151","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}