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The result of the human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) <jats:italic>in situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">ISH<\/jats:styled-content>) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>\u2010positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067, and p53. Moreover, they harbored the identical <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> gene mutation suggesting that there was a common origin. Somatic <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.<\/jats:p>","DOI":"10.1111\/pin.12173","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T09:56:23Z","timestamp":1403776583000},"page":"283-288","source":"Crossref","is-referenced-by-count":9,"title":["Gastric\u2010type endocervical glandular neoplasms associated with aberrant p16 expression and <scp>K<\/scp>\u2010<scp>RAS<\/scp> gene mutation in <scp>P<\/scp>eutz\u2010<scp>J<\/scp>eghers syndrome"],"prefix":"10.1111","volume":"64","author":[{"given":"Shigemi","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Pathology Miyagi Cancer Center  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Tase","sequence":"additional","affiliation":[{"name":"Department of Gynecology Miyagi Cancer Center  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennichi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Cancer Stem Cell Miyagi Cancer Research Institute  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Pathology Miyagi Cancer Center  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Miyagi Cancer Center  Natori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"168","volume-title":"WHO Classification of Tumours. 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