{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:39:49Z","timestamp":1776087589722,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Esophageal adenocarcinomas usually develop in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's esophagus, typically through the metaplasia\u2013dysplasia\u2013carcinoma sequence, but adenocarcinomas can occur from heterotopic gastric mucosa in cervical esophagus (inlet patch). This report describes the first case of synchronous presentation of adenocarcinoma arising from cervical inlet patch and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's esophagus\u2010related dysplasia in a 76\u2010year\u2010old man. Surveillance <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> detected a 3\u2010cm polypoid mass in the cervical esophagus. Endoscopic biopsies confirmed a diagnosis of adenocarcinoma of the cervical esophagus. <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's esophagus was present also in the lower esophagus. Histologic examination of the surgically resected specimen revealed the polypoid mass as composed of tubular adenocarcinoma, and was associated with non\u2010neoplastic columnar mucosa representing pre\u2010existing inlet patch. Another isolated cervical inlet patch with intestinal metaplasia was also recognized. In the lower esophagus, high\u2010grade dysplasia was noted within the Barrett's esophagus. Immunohistochemically, the adenocarcinoma associated with inlet patch had intestinal immunophenotype (<jats:styled-content style=\"fixed-case\">CDX2<\/jats:styled-content>\u2010, <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">MUC2<\/jats:styled-content>\u2010positive), whereas the Barrett's esophagus\u2010related high\u2010grade dysplasia showed mixed immunophenotype (<jats:styled-content style=\"fixed-case\">MUC5AC<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>\u2010positive, with scattered <jats:styled-content style=\"fixed-case\">MUC2<\/jats:styled-content>\u2010positive goblet cells). Previous studies and our findings suggest that intestinal metaplasia might predispose to the development of adenocarcinoma in the inlet patch. Therefore, endoscopists and pathologists should be aware of rare malignant transformation of inlet patches, especially those with intestinal metaplasia.<\/jats:p>","DOI":"10.1111\/pin.12181","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T23:49:05Z","timestamp":1408664945000},"page":"397-401","source":"Crossref","is-referenced-by-count":17,"title":["Esophageal adenocarcinoma arising in cervical inlet patch with synchronous <scp>B<\/scp>arrett's esophagus\u2010related dysplasia"],"prefix":"10.1111","volume":"64","author":[{"given":"Mariko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Pathology and Diagnostic Pathology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[{"name":"Department of Pathology and Diagnostic Pathology Graduate School of Medicine The University of Tokyo  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