{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:09Z","timestamp":1740126009539,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"To investigate the clinicopathological and prognostic significance of a nodular pattern and immunophenotypes in primary mediastinal large B<\/jats:styled-content>\u2010cell lymphoma (PMBL<\/jats:styled-content>), histopathological features, including a nodular pattern and immunophenotypes, were analyzed in 58 J<\/jats:styled-content>apanese PMBL<\/jats:styled-content> patients. The patients were 23 men and 35 women with a median age of 31 years. The 4\u2010year progression free survival (PFS<\/jats:styled-content>) rate was 78%, and the 4\u2010year overall survival (OS<\/jats:styled-content>) rate was 89%. Among the histopathological and immunohistochemical features, Bcl6+<\/jats:sup> (P<\/jats:italic> = 0.013), MUM1<\/jats:styled-content>+<\/jats:sup> (P<\/jats:italic> = 0.091), and pale cytoplasm (P<\/jats:italic> = 0.064) were favorable prognostic indicators of PFS<\/jats:styled-content>, and Bcl6+<\/jats:sup> (P<\/jats:italic> = 0.051) and MUM1<\/jats:styled-content>+<\/jats:sup> (P<\/jats:italic> = 0.07) were favorable prognostic indicators of OS<\/jats:styled-content>. Patients with Bcl2 negativity (n<\/jats:italic> = 11) had 4\u2010year PFS<\/jats:styled-content> and OS<\/jats:styled-content> rates of 100%. Histologically, a nodular pattern, resembling nodular sclerosis classical Hodgkin lymphoma (CHL<\/jats:styled-content>), was observed in 22 patients (38%). However, this was not a significant prognostic indicator. In conclusion, Bcl6+<\/jats:sup>, MUM1<\/jats:styled-content>+<\/jats:sup>, Bcl2\u2010<\/jats:sup>, and pale cytoplasm are candidate favorable prognostic indicators for PMBL<\/jats:styled-content> and should be further examined in larger studies. We suggest that PMBL<\/jats:styled-content> with a nodular pattern may belong to the same histological spectrum as nodular sclerosis CHL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pin.12186","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T23:49:05Z","timestamp":1408664945000},"page":"382-387","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of immunophenotypes and a nodular pattern in primary mediastinal large B<\/scp>\u2010cell lymphoma"],"prefix":"10.1111","volume":"64","author":[{"given":"Akiko Miyagi","family":"Maeshima","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Laboratory National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratory National Cancer Center Hospital Tokyo 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