{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:39:22Z","timestamp":1762623562475},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Heart transplantation started in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan in 1999. Since then, 50 transplants have been performed at our center. We performed histopathological analyses of the 50 explanted hearts and the post\u2010transplant biopsy specimens. The median age of recipients was 39 years. The primary diseases before transplant were idiopathic dilated cardiomyopathy in 33 patients (66%), hypertrophic cardiomyopathy in seven (14%), restrictive cardiomyopathy in one, arrhythmogenic right ventricular cardiomyopathy in one, and secondary cardiomyopathy in eight (16%). Before transplantation, 47 patients (94%) had left ventricular assist devices. No severe cardiovascular failure due to allograft rejection occurred. The post\u2010transplant survival rate was 97.6% at 1 year and 93.1% at 10 years. One recipient was lost to sepsis from myelodysplastic syndrome in the fourth year, one died of multiple organ failure and peritonitis 8 months after transplant. Another patient died of recurrent post\u2010transplant lymphoproliferative disorders (<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>). Mild cardiac dysfunction occurred in seven recipients in the early postoperative period. Moderate acute cellular rejection occurred in six patients (12%), and antibody\u2010mediated rejection occurred in three (6%). The number of heart transplants performed in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan is very small. However, the outstanding 10\u2010year survival rate is due to donor evaluation and post\u2010transplant care resulting in low grade rejection. Pathological evaluation has also greatly contributed to the results.<\/jats:p>","DOI":"10.1111\/pin.12189","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T09:24:58Z","timestamp":1408699498000},"page":"423-431","source":"Crossref","is-referenced-by-count":5,"title":["The pathological implications of heart transplantation: Experience with 50 cases in a single center"],"prefix":"10.1111","volume":"64","author":[{"given":"Hatsue","family":"Ishibashi\u2010Ueda","sequence":"first","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center  Suita Osaka 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