{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:00:35Z","timestamp":1773180035912,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Primary intestinal follicular lymphoma (FL<\/jats:styled-content>) is a variant of FL<\/jats:styled-content> characterized by frequent duodenal involvement and a very indolent clinical behavior without therapy. Unlike nodal FL<\/jats:styled-content>, there have been no reports of histologic transformation (HT<\/jats:styled-content>) or death attributable to primary intestinal FL<\/jats:styled-content>. Here, we report the first case of primary duodenal FL<\/jats:styled-content> showing HT<\/jats:styled-content>. A Grade 1 FL<\/jats:styled-content> in the duodenum was incidentally detected in a 73\u2010year\u2010old man. A watch\u2010and\u2010wait strategy was adopted because the disease was stage IE<\/jats:styled-content>. Six months later, bone marrow involvement was suspected. The intestinal lesions had not changed during the first year since the initial diagnosis. Sixty\u2010two months after the initial diagnosis, a biopsy specimen showed diffuse large B<\/jats:styled-content>\u2010cell lymphoma (DLBCL<\/jats:styled-content>). A perforation of the intestine occurred before chemotherapy was started. Partial resection was performed and subsequent chemotherapy was administered. The clone of the initial FL<\/jats:styled-content> and DLBCL<\/jats:styled-content> were identical according to PCR<\/jats:styled-content> analysis, indicating that the primary intestinal FL<\/jats:styled-content> had transformed into DLBCL<\/jats:styled-content>. Although HT<\/jats:styled-content> is rare, it could occur in some patients with primary intestinal FL<\/jats:styled-content>. Based on this case, it may be necessary to re\u2010evaluate the clinical watch\u2010and\u2010wait strategy for primary intestinal FL<\/jats:styled-content> in some patients.<\/jats:p>","DOI":"10.1111\/pin.12197","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T09:27:17Z","timestamp":1409736437000},"page":"527-532","source":"Crossref","is-referenced-by-count":28,"title":["A case of diffuse large B<\/scp>\u2010cell lymphoma transformed from primary duodenal follicular lymphoma"],"prefix":"10.1111","volume":"64","author":[{"given":"Tomoko","family":"Miyata\u2010Takata","sequence":"first","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Okayama Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Okayama Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01980.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9193"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008282818705"},{"key":"e_1_2_5_6_1","first-page":"1860","article-title":"Report of the Committee on Hodgkin's Disease Staging Classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.51"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.871634"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.5.1282.1282"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.3260"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12392"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl162"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.027"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.7577"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2856"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:13:35Z","timestamp":1696000415000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,3]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/pin.12197"],"URL":"https:\/\/doi.org\/10.1111\/pin.12197","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,3]]}}}