{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:28:34Z","timestamp":1780712914388,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Ministry of Environment","award":["2012001350013"],"award-info":[{"award-number":["2012001350013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care and prognosis. But, this distinction can be extremely difficult, particularly in small biopsies. Recently, insulin\u2010like growth factor II mRNA<\/jats:styled-content>\u2010binding protein 3 (IMP3<\/jats:styled-content>) and glucose transporter 1 (GLUT<\/jats:styled-content>\u20101) have been reported as specific and sensitive markers in the distinction of mesotheliomas from benign mesothelial proliferations. The purpose of this study is to evaluate the utility of IMP3<\/jats:styled-content>, GLUT<\/jats:styled-content>\u20101, and epithelial membrane antigen (EMA<\/jats:styled-content>) immunohistochemistry for distinguishing mesotheliomas from benign mesothelial proliferations. Immunoexpression of IMP3<\/jats:styled-content>, GLUT<\/jats:styled-content>\u20101, and EMA<\/jats:styled-content> was evaluated in 88 malignant mesotheliomas, 35 adenomatoid tumors, and 20 benign lung tissues with reactive mesothelial cells. The sensitivity for IMP3<\/jats:styled-content>, GLUT<\/jats:styled-content>\u20101, and EMA<\/jats:styled-content> was 37%, 21%, and 41%, respectively. The specificity for IMP3<\/jats:styled-content>, GLUT<\/jats:styled-content>\u20101, and EMA<\/jats:styled-content> was 100%. When IMP3<\/jats:styled-content>, GLUT1<\/jats:styled-content>, and EMA<\/jats:styled-content> combined, the sensitivity was 66% for IMP3<\/jats:styled-content>\/EMA<\/jats:styled-content> staining, 53% for GLUT<\/jats:styled-content>\u20101\/EMA<\/jats:styled-content> staining, and 45% for IMP3<\/jats:styled-content>\/GLUT<\/jats:styled-content>\u20101. Use of IMP3<\/jats:styled-content> and EMA<\/jats:styled-content> together is more helpful to distinguish malignant mesotheliomas from benign mesothelial proliferations than the use of IMP3<\/jats:styled-content> or EMA<\/jats:styled-content> alone.<\/jats:p>","DOI":"10.1111\/pin.12216","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T04:47:14Z","timestamp":1415335634000},"page":"607-612","source":"Crossref","is-referenced-by-count":18,"title":["Practical utility of insulin\u2010like growth factor II mRNA<\/scp>\u2010binding protein 3, glucose transporter 1, and epithelial membrane antigen for distinguishing malignant mesotheliomas from benign mesothelial proliferations"],"prefix":"10.1111","volume":"64","author":[{"given":"Sunhee","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pathology Inje University Ilsan Paik Hospital Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee\u2010Hye","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology Soonchunhyang University College of Medicine Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u2010Young","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joungho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseob","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology Keimyung University School of Medicine Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yeon","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pathology Gachon University Gil Hospital Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Pusan National University School of Medicine Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon\u2010Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0112-RA"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02442.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00866-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818aada9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181483ff8"},{"key":"e_1_2_6_7_1","first-page":"437","article-title":"Expression of facilitative glucose transporter isoforms in lung carcinomas: Its relation to histologic type, differentiation grade, and tumor stage","volume":"11","author":"Ito T","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<194::AID-IJC6>3.0.CO;2-M"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339259"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23254"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.04.030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21398"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826ab1c0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318218985b"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20071"},{"key":"e_1_2_6_17_1","first-page":"663","article-title":"Immunohistochemistry of cytokeratins 7, 8, 17, 18, and 19, and GLUT\u20101 aids differentiation of desmoplastic malignant mesothelioma from fibrous pleuritis","volume":"28","author":"Horiuchi T","year":"2013","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800732"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21800"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0219-OA"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1344-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPP5R2ZJZKCLWN"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPWFW7O1FVFLKT"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092085"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5KNL7QTELLYI"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.134"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22821"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10923"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.45"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02534.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPT94JVWIHBKRD"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:55:35Z","timestamp":1695542135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/pin.12216"],"URL":"https:\/\/doi.org\/10.1111\/pin.12216","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}