{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:33Z","timestamp":1740126033580,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"crossref","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"We here report on two rare cases of intrafollicular classical Hodgkin lymphoma (CHL<\/jats:styled-content>). Case 1 was a 34\u2010year\u2010old man who underwent left supraclavicular lymph node biopsy. Case 2 was a 28\u2010year\u2010old woman who underwent surgical resection of an anterior mediastinal mass. The histology and microenvironment of both specimens resembled those of nodular lymphocyte predominant Hodgkin lymphoma. Nodular architecture was observed, which comprised normal\u2010appearing small lymphocytes and scattered lymphocyte predominant (LP<\/jats:styled-content>)\u2010like cells. CD23<\/jats:styled-content>+<\/jats:sup> follicular dendritic cell meshworks were present in the nodules, surrounded by a mantle zone containing IgD<\/jats:styled-content>+<\/jats:sup> B<\/jats:styled-content> cells. The LP<\/jats:styled-content>\u2010like cells were ringed by CD3<\/jats:styled-content>+<\/jats:sup> and PD<\/jats:styled-content>\u20101+<\/jats:sup> T<\/jats:styled-content> cells, and numerous CD20<\/jats:styled-content>+<\/jats:sup> B<\/jats:styled-content> cells were present in the background. However, the immunophenotypes of the LP<\/jats:styled-content>\u2010like cells resembled those of Hodgkin\/Reed\u2010Sternberg cells of CHL<\/jats:styled-content>; they were positive for CD15<\/jats:styled-content>, CD30<\/jats:styled-content>, and PAX5<\/jats:styled-content>, and negative for CD20<\/jats:styled-content>, Bcl6, Oct2<\/jats:styled-content>, and Bob1. These histopathological findings indicate that CHL<\/jats:styled-content> can be derived from the germinal center.<\/jats:p>","DOI":"10.1111\/pin.12221","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T03:29:25Z","timestamp":1415849365000},"page":"613-617","source":"Crossref","is-referenced-by-count":0,"title":["Intrafollicular classical H<\/scp>odgkin lymphoma mimicking nodular lymphocyte predominant H<\/scp>odgkin lymphoma: A report of two cases"],"prefix":"10.1111","volume":"64","author":[{"given":"Mai","family":"Tatsuno","sequence":"first","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital Tokyo Japan"},{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital Tokyo 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