{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:45:42Z","timestamp":1787791542217,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Lanthanum carbonate is one of the new phosphate binders used for the treatment of hyperphosphatemia in patients with chronic kidney disease. It is poorly absorbed from the gastrointestinal tract, forms insoluble complexes within the lumen, and prevents the absorption of dietary phosphate. A 63\u2010year\u2010old female with a 7\u2010year history of peritoneal dialysis, who was treated with lanthanum carbonate for four years, underwent endoscopic submucosal dissection for intramucosal gastric cancer. Resected specimens showed massive accumulation of macrophages containing fine, granular, brown material in the lamina propria. This was confirmed as lanthanum deposition by scanning electron microscopy with energy dispersive x\u2010ray spectroscopy. Although lanthanum may be poorly absorbed, increased tissue accumulation of lanthanum, particularly in the liver and bone, has been reported in animals with chronic kidney disease. This report indicates enhanced gastrointestinal absorption of lanthanum in some patients or conditions, although its clinical significance awaits further studies.<\/jats:p>","DOI":"10.1111\/pin.12227","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T01:31:22Z","timestamp":1416533482000},"page":"33-37","source":"Crossref","is-referenced-by-count":53,"title":["Extensive lanthanum deposition in the gastric mucosa: The first histopathological report"],"prefix":"10.1111","volume":"65","author":[{"given":"Mutsuki","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Shinonoi General Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shinonoi General Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Pathology SHINSHU University School of Medicine  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinonoi General Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shinonoi General Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shinonoi General Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847090-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00171.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00753.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp364"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.146"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.571"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000118"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl146"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.7.754"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/oxfordjournals.ndt.a091716","article-title":"Enhanced gastrointestinal absorption of aluminium in uraemia: Time course and effect of vitamin D","volume":"3","author":"Ittel TH","year":"1988","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353764"},{"key":"e_1_2_7_13_1","first-page":"608","article-title":"Pathology of gastrointestinal tract in chronic hemodialysis patients: An autopsy study of 78 cases","volume":"80","author":"Vaziri ND","year":"1985","journal-title":"Am J Gastroenterol"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:53:28Z","timestamp":1695574408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,20]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/pin.12227"],"URL":"https:\/\/doi.org\/10.1111\/pin.12227","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,20]]}}}