{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:47:13Z","timestamp":1785930433401,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) is a plasma\u2010cell neoplasm that can cause renal disorders. Renal lesions in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> can present with a very rare pathological manifestation involving a specific monoclonal immunoglobulin (<jats:styled-content style=\"fixed-case\">Ig<\/jats:styled-content>). We report the case of a 33\u2010year\u2010old woman who had edema, fatigue, elevated serum creatinine levels, hypoalbuminemia, and hypercholesterolemia. She had persistent hematuria and proteinuria lasting 3 years. Serum protein electrophoresis showed an <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\u2010spike, and serum immunofixation demonstrated the presence of monoclonal <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> \u03bb. She had proteinuria in the nephrotic range, and a monoclonal \u03bb fragment was present on urine immunofixation. Renal biopsy showed proliferative glomerulonephritis with \u03bb light chain and <jats:styled-content style=\"fixed-case\">C3c<\/jats:styled-content> deposition and inflammatory cell infiltration with <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content>. Macrophage lysosomes contained \u03bb light chains, suggesting their partial phagocytosis. She was diagnosed with symptomatic <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> and was treated with bortezomib and dexamethasone and an autologous peripheral stem cell transplant conditioned with intravenous melphalan. She achieved a partial response with decreased serum monoclonal protein and improved renal function. This case may be categorized as a monoclonal gammopathy\u2010associated proliferative glomerulonephritis. The biopsy finding of partially phagocytosed Ig \u03bb light chains by macrophages is very rare; this pathological condition is similar to crystal\u2010storing histiocytosis.<\/jats:p>","DOI":"10.1111\/pin.12229","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T06:05:30Z","timestamp":1416463530000},"page":"38-42","source":"Crossref","is-referenced-by-count":10,"title":["A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain"],"prefix":"10.1111","volume":"65","author":[{"given":"Hirofumi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Niigata Rinko Hospital  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