{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:37:54Z","timestamp":1783463874375,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Acquired cystic disease (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>)\u2010associated renal cell carcinoma (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) has recently been established. Herein we report the sixth case of <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> with a sarcomatoid change. The patient was a 77\u2010year\u2010old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> nephropathy. On computed tomography, a large right <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan\u2010to\u2010yellow tumor (95 \u00d7 75 \u00d7 55\u2009mm) with a whitish nodule (20 \u00d7 15 \u00d7 15\u2009mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the <jats:italic><jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53<\/jats:italic> mutation.<\/jats:p>","DOI":"10.1111\/pin.12232","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T09:59:33Z","timestamp":1416995973000},"page":"89-94","source":"Crossref","is-referenced-by-count":11,"title":["Acquired cystic disease\u2010associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component"],"prefix":"10.1111","volume":"65","author":[{"given":"Shogo","family":"Tajima","sequence":"first","affiliation":[{"name":"Department of Pathology Shizuoka Saiseikai General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiko","family":"Waki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy Hamamatsu University School of Medicine  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Urology Shizuoka Saiseikai General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Shizuoka Saiseikai General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syunsuke","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Urology Shizuoka Saiseikai General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Department of Urology Shizuoka Saiseikai General Hospital  Shizuoka 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