{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:38:50Z","timestamp":1768070330196,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>We present a case of adrenal rest tumor of the liver in which differential diagnosis from lipid rich\u2010hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) was challenging. The patient was a 50\u2010year\u2010old woman in whom a 3\u2010cm tumorous mass was discovered in segment 7 of the liver during computed tomography evaluation of a uterine leiomyoma. The preoperative diagnosis was <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, and subsegmental liver resection was performed. The tumor appeared as a well\u2010demarcated golden yellow nodule consisting of clear or partially eosinophilic cells arranged in a trabecular pattern. The initial impression of this lesion was that of clear cell type or lipid\u2010rich type <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> because it stained positive for Hep Par1, but negative for arginase\u20101 and positive for <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> which is one of the neuroendocrine markers. The lesion also stained positive for <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u20101 and 3\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>, both of which are markers of adrenocortical tissue. The final diagnosis was hepatic adrenal rest tumor. Hepatic adrenal rest tumor should be considered in the differential diagnosis of segment 7 tumor. A diagnostic algorithm that includes immunohistochemical staining for <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> and arginase\u20101 is to rule out the possibility of lipid\u2010rich <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pin.12234","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T09:49:23Z","timestamp":1420796963000},"page":"95-99","source":"Crossref","is-referenced-by-count":19,"title":["Hepatic adrenal rest tumor: Diagnostic pitfall and proposed algorithms to prevent misdiagnosis as lipid\u2010rich hepatocellular carcinoma"],"prefix":"10.1111","volume":"65","author":[{"given":"Tomoko","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Tokai University Hachioji Hospital  Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tokai University Hachioji Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouske","family":"Tobita","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokai University Hachioji Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"152","volume-title":"Atlas of Tumor Pathology: Tumors of the Liver and Intrahepatic Bile Ducts, Third Series, Fascicle 31","author":"Ishak 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