{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:46:55Z","timestamp":1789969615208,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MEXT KAKENHI Grant-in-Aid for Young Scientists (B)","award":["25860282"],"award-info":[{"award-number":["25860282"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Apocrine carcinoma is categorized as a special type of breast carcinoma because of its specific morphological features. To clarify the characteristics of apocrine carcinoma from the point of view of the mitochondrial profile, we conducted a comparative study between apocrine and non\u2010apocrine carcinomas. The expressions of mitochondrial related factors (<jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf1, <jats:styled-content style=\"fixed-case\">Nrf2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">mtTFA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">COX4<\/jats:styled-content>) were examined in a testing set of breast cancer tissue. Apocrine carcinomas showed a clear tendency towards higher <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels of <jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content> than non\u2010apocrine carcinomas. The expression of the selected factor, <jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content>, as well as that of p62 was further examined. The results revealed that apocrine carcinomas showed a higher immunohistochemical positivity rate for <jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content> (21.3% vs. 3.2%; <jats:italic>P<\/jats:italic> = 0.008), and that the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression level of <jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content> was significantly higher in apocrine carcinoma than in non\u2010apocrine carcinoma (<jats:italic>P<\/jats:italic> = 0.007). The immunohistochemical positivity rate for p62 protein was also higher in apocrine carcinomas (44.7% vs. 21.0%; <jats:italic>P<\/jats:italic> = 0.015), although no significant difference in the p62 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression level was detected between the two types of carcinoma (<jats:italic>P<\/jats:italic> = 0.633). In conclusion, this study revealed that apocrine carcinoma overexpressed <jats:styled-content style=\"fixed-case\">PGC1\u03b1<\/jats:styled-content> contributing to mitochondrial biogenesis, and also p62 protein accumulation.<\/jats:p>","DOI":"10.1111\/pin.12235","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T01:49:20Z","timestamp":1418780960000},"page":"19-26","source":"Crossref","is-referenced-by-count":10,"title":["Overexpression of <scp>PGC1\u03b1<\/scp> and accumulation of p62 in apocrine carcinoma of the breast"],"prefix":"10.1111","volume":"65","author":[{"given":"Fumi","family":"Fuchinoue","sequence":"first","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Hirotani","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Functional Morphology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Nishimaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Sugitani","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimichi","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Pathology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02790.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913128009141441"},{"key":"e_1_2_7_4_1","first-page":"532","article-title":"Apocrine carcinoma of the breast. 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