{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:49:37Z","timestamp":1695620977725},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>An autopsy case of leptomeningeal melanomatosis associated with neurocutaneous melanosis (<jats:styled-content style=\"fixed-case\">NCM<\/jats:styled-content>) involving a 44\u2010year\u2010old male is reported. The autopsy showed that the leptomeningeal surface of the brain and the spinal cord were covered with a diffuse black lesion. A histological examination detected diffusely distributed, proliferating, melanin\u2010containing cells and demonstrated that the lesion consisted of three different components; i.e. regions of melanomatosis, melanocytosis, and melanocyte hyperplasia. In the leptomeningeal melanomatosis component, tumor cells with pleomorphic nuclei and prominent nucleoli had infiltrated into the cerebral parenchyma via <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>irchow\u2013<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>obin spaces. The <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 labeling index and the nuclear accumulation of p53 and p16 protein were immunohistochemically examined in each component. The <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 labeling indices of the melanomatosis, melanocytosis, and melanocyte hyperplasia components were 8.7%, 0.8%, and 0%, respectively. Immunostaining of nuclear p16 produced a negative result in the melanomatosis component, but positive results in the melanocytosis and melanocyte hyperplasia components, whereas nuclear p53 expression was not detected in any of the components. This case suggests that p16<jats:sup>INK4<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CDKN2<\/jats:styled-content> may play a significant role in progression of leptomeningeal melanocytic neoplasms. We also reviewed previously reported cases of leptomeningeal neoplasms associated with <jats:styled-content style=\"fixed-case\">NCM<\/jats:styled-content> and discussed the relationship between the biological behavior and proliferative activity of such lesions.<\/jats:p>","DOI":"10.1111\/pin.12238","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T09:05:12Z","timestamp":1418807112000},"page":"100-105","source":"Crossref","is-referenced-by-count":3,"title":["Leptomeningeal melanomatosis associated with neurocutaneous melanosis: An autopsy case report"],"prefix":"10.1111","volume":"65","author":[{"given":"Mai","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okudela","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Saiseikai Yokohamashi Nanbu Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Inayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70115-I"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.01.017"},{"key":"e_1_2_7_4_1","first-page":"113","article-title":"Ein Ausgezeichneter fall von pigment\u2010mall mit ausgebreiteter pigmentirung der imerien him\u2010und riickenmarkshaute","volume":"6","author":"Rokitansky J","year":"1861","journal-title":"Allg Wien Med Z"},{"key":"e_1_2_7_5_1","first-page":"414","volume-title":"Handbook of Clinical Neurology","author":"Fox H","year":"1972"},{"key":"e_1_2_7_6_1","first-page":"181","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Brat DJ","year":"2007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006127619926"},{"key":"e_1_2_7_8_1","first-page":"94","article-title":"An autopsy case of neurocutaneous melanosis with malignant transformation","volume":"42","author":"Inoue T","year":"2005","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00619.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.55418\/9781933477107","volume-title":"Melanocytic Tumors of the Skin","author":"Elder DE","year":"2010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.55418\/9781933477015-ch14","volume-title":"Tumors of the Central Nervous System","author":"Burger PC","year":"2007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.43.619"},{"key":"e_1_2_7_13_1","first-page":"500","article-title":"Progressive brainstem compression in an infant with neurocutaneous melanosis and Dandy\u2010Walker complex following ventriculoperitoneal shunt placement for hydrocephalus. 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