{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:28:18Z","timestamp":1770823698072,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Encapsulated papillary carcinoma (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>) and solid papillary carcinoma (<jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>) are distinctive variants of intraductal papillary carcinomas, each accounting for &lt;1% of breast carcinomas. Here we report a composite carcinoma consisting of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>. A 73\u2010year\u2010old woman was found to have a high density mass in the left breast on mammogram. A biopsy showed intermediate to high grade ductal carcinoma in situ (<jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content>). Gross examination of the lumpectomy specimen revealed a solid, multinodular mass. Microscopic examination demonstrated two morphologically distinct intraductal carcinomas intermingled with each other. One had delicate papillae in multi\u2010cystic spaces surrounded by thick fibrous capsule, consistent with <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>. The other had solid tumor nests with delicate fibrovascular cores. The cells were monotonous with round nuclei and salt and pepper\u2010like chromatin, characteristic of <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>. The lack of myoepithelial cells within the papillae and at the periphery of the lesion was confirmed by immunostaining for p63 and <jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content>\/6. Neuroendocrine differentiation of <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content> was demonstrated by neuron specific enolase staining. To our knowledge, this is the first reported case of composite <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>. It raises an interesting question as to a possible common pathway of carcinogenesis of these two rare variants.<\/jats:p>","DOI":"10.1111\/pin.12239","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T08:39:11Z","timestamp":1419410351000},"page":"133-137","source":"Crossref","is-referenced-by-count":8,"title":["Composite encapsulated papillary carcinoma and solid papillary carcinoma"],"prefix":"10.1111","volume":"65","author":[{"given":"Xiaoyan","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23723"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e318032508d"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830701)52:1<14::AID-CNCR2820520104>3.0.CO;2-N"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90250-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90420-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200608000-00011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821b3f65"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP8A2UVLCYGTPU"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896906299119"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00941-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200710"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.136"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199511000-00003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2004.03.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.5858\/2001-125-1101-MPAWAP","article-title":"Metastatic prostatic adenocarcinoma within a primary solid papillary carcinoma of the male breast","volume":"125","author":"Sahoo S","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2007.02118.x"},{"key":"e_1_2_6_19_1","volume-title":"WHO Classification of Tumors of the Breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3032"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198711000-00033"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.2.2649917"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:08:46Z","timestamp":1695539326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,24]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/pin.12239"],"URL":"https:\/\/doi.org\/10.1111\/pin.12239","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,24]]}}}