{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:43:46Z","timestamp":1792755826082,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content>cam (<jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content>), one of the cell adhesion molecules belonging to the immunoglobulin superfamily, plays critical roles in neuronal migration, axon growth, guidance, fasciculation, and synaptic plasticity in the central as well as the peripheral nervous system. A number of <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010linked forms of mental retardation have been associated with mutations in the <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content> gene, including <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010linked hydrocephalus in humans. Although model mice with different sites of <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content> mutation have been studied, the pathogenetic mechanisms of hydrocephalus and mental retardation still remain unsolved. We herein present an overview of the function of <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content> in the central nervous system and describe a human case of <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content> mutation and knock\u2010in mice that showed deleted sixth immunoglobulin of <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content>. Finally, we present experimental evidence showing that <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content> is involved in murine neocortical histogenesis and propose a hypothetical mechanism of <jats:styled-content style=\"fixed-case\">L1<\/jats:styled-content>\u2010linked hydrocephalus, with reference to corticogenesis.<\/jats:p>","DOI":"10.1111\/pin.12245","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T04:34:43Z","timestamp":1422851683000},"page":"58-66","source":"Crossref","is-referenced-by-count":40,"title":["The role of <scp>L1<\/scp>cam in murine corticogenesis, and the pathogenesis of hydrocephalus"],"prefix":"10.1111","volume":"65","author":[{"given":"Kyoko","family":"Itoh","sequence":"first","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto 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