{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:32:57Z","timestamp":1789169577150,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>We present three cases of melanotic oncocytic metaplasia of the nasopharynx. Case 1 and Case 2 were a 70\u2010 and a 61\u2010year\u2010old woman, and Case 3 was a 74\u2010year\u2010old man. Although Case 1 was asymptomatic, Cases 2 and 3 had hoarseness. All cases were Japanese and their nasopharyngeal examination revealed single or multiple black nodules measuring a few millimeters in diameter. In each case, biopsies were performed to rule out malignancy. Histological examination showed respiratory mucosa with oncocytic metaplasia and melanin pigments. Immunohistochemically, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010100 protein and melan\u2010A positive dendritic melanocytes were observed in the basal layer of the oncocytes. Melanotic oncocytic metaplasia is extremely rare, and so far only 21 cases have been reported in the English literature to our knowledge. It has been reported in only older Asians, predominantly in males; there have been only three female patients including our two cases. All of our cases were long\u2010time smokers, which supports the previously described hypothesis that smoking may be a predisposing factor for melanin pigmentation. Since melanotic oncocytic metaplasia may clinically mimic a malignant tumor, it is important to be aware of this lesion.<\/jats:p>","DOI":"10.1111\/pin.12247","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T07:27:56Z","timestamp":1420788476000},"page":"144-147","source":"Crossref","is-referenced-by-count":9,"title":["Melanotic oncocytic metaplasia of the nasopharynx"],"prefix":"10.1111","volume":"65","author":[{"given":"Keiichiro","family":"Uehara","sequence":"first","affiliation":[{"name":"Department of Pathology Saitama Medical University, Saitama International Medical Center  Saitama Japan"},{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Usami","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Hyogo Japan"},{"name":"Division of Clinical Laboratory Osaka University Dental Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Kobe City Medical Center General Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University, Saitama International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-5-5"},{"key":"e_1_2_6_3_1","first-page":"461","volume-title":"Histology for Pathologists","author":"Mills SE","year":"2012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb01442.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050366"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2004.01.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690501300308"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1997.tb04499.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0970-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.035005481.x"},{"key":"e_1_2_6_11_1","first-page":"1230","article-title":"Images for diagnosis. Melanotic oncocytic metaplasia of nasopharynx: A case report with review","volume":"123","author":"Li Y","year":"2010","journal-title":"Chin Med J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020412331283860"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2012.46.2.201"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2014.43969"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:08:44Z","timestamp":1695539324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/pin.12247"],"URL":"https:\/\/doi.org\/10.1111\/pin.12247","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]}}}