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In this study, we describe the morphologic, immunohistochemical features of incidentally discovered appendiceal carcinoids entirely represented by clear cells in a 22\u2010year\u2010old man and a 52\u2010year\u2010old woman. Ultrastructual examination demonstrated abundant lipid droplets and dense core granules. The mechanism leading to lipid accumulation in the cytoplasm has not been discovered, but degenerative processes following recurrent inflammatory change might be considered. This uncommon variant of appendiceal classic carcinoid tumors may bear a superficial resemblance to goblet carcinoid and\/or appendiceal metastases from clear cell carcinoma. Awareness of clear cell carcinoid of the appendix will prevent incorrect diagnosis and unnecessary aggressive management.<\/jats:p>","DOI":"10.1111\/pin.12284","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T05:28:48Z","timestamp":1427261328000},"page":"324-328","source":"Crossref","is-referenced-by-count":3,"title":["Clear cell carcinoid of the appendix: Report of two cases with literature review"],"prefix":"10.1111","volume":"65","author":[{"given":"Gu Hyum","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chungnam National University College of Medicine  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University College of Medicine  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungnam National University College of Medicine  Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236899"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0545-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90415-3"},{"key":"e_1_2_6_5_1","first-page":"630","article-title":"Appendiceal carcinoids: Correlation of histology and immunohistochemistry","volume":"2","author":"Burke AP","year":"1989","journal-title":"Mod Pathol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ce9204"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP0NWA1DBDZIOY"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-010-9132-9"},{"key":"e_1_2_6_9_1","first-page":"126","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman FT","year":"2010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/1066896910379404","article-title":"Goblet cell carcinoid of the appendix: A clinicopathological and immunohistochemical study of 26 cases from southwest China","volume":"18","author":"Jiang Y","year":"2010","journal-title":"Int J Surg Pathol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-007-0004-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/79.4.512"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000184819.71752.ad"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00105.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.5858\/2003-127-745-CCCTOT","article-title":"Clear cell carcinoid tumor of the gallbladder. 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