{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:51Z","timestamp":1792800051951,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Intraductal papillary lesions of the breast constitute a heterogeneous entity, including benign intraductal papilloma (<jats:styled-content style=\"fixed-case\">IDP<\/jats:styled-content>) with or without atypia and malignant papillary carcinoma. Differentiating between these diagnoses can be challenging. We re\u2010evaluated core biopsy specimens that were diagnosed as <jats:styled-content style=\"fixed-case\">IDP<\/jats:styled-content> and the corresponding surgical excision specimens, and assessed the potential risk for the diagnosis to be modified to malignancy based on excision. By sorting the pathology database of the National Cancer Center Hospital, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>okyo, we identified 146 core biopsy cases that were histologically diagnosed as <jats:styled-content style=\"fixed-case\">IDP<\/jats:styled-content> between 1997 and 2013. The re\u2010evaluated diagnosis was <jats:styled-content style=\"fixed-case\">IDP<\/jats:styled-content> without atypia in 79 (54%) patients, <jats:styled-content style=\"fixed-case\">IDP<\/jats:styled-content> with atypia in 66 (45%), and ductal carcinoma in situ (<jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content>) in 1 (1%). Among the 34 patients (23%) who underwent surgical excision subsequent to core biopsy, histological diagnosis was upgraded to carcinoma, excluding lobular carcinoma in situ (<jats:styled-content style=\"fixed-case\">LCIS<\/jats:styled-content>), in 14 (41%) cases, including 4 (33%) of 12 <jats:styled-content style=\"fixed-case\">IDPs<\/jats:styled-content> without atypia and 10 (45%) of 22 <jats:styled-content style=\"fixed-case\">IDPs<\/jats:styled-content> with atypia. Complete surgical excision should be kept in mind for all <jats:styled-content style=\"fixed-case\">IDPs<\/jats:styled-content> diagnosed on core biopsy, not only <jats:styled-content style=\"fixed-case\">IDPs<\/jats:styled-content> with atypia but <jats:styled-content style=\"fixed-case\">IDPs<\/jats:styled-content> without atypia, especially when clinical or imaging diagnosis findings cannot rule out the possibility of malignancy, because papillary lesions comprise a variety of morphological appearances.<\/jats:p>","DOI":"10.1111\/pin.12285","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T16:38:02Z","timestamp":1426869482000},"page":"293-300","source":"Crossref","is-referenced-by-count":54,"title":["Intraductal papillomas on core biopsy can be upgraded to malignancy on subsequent excisional biopsy regardless of the presence of atypical 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