{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:24:14Z","timestamp":1762017854696},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Grant of National Center for Child Health and Development, Japan","award":["24-4"],"award-info":[{"award-number":["24-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Infantile myofibromatosis (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) is a rare disorder present at birth or in early infancy with a biphasic histological pattern. We present a neonatal\u2010onset case of generalized <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> with visceral (central nervous system, heart, lungs, liver, spleen, small intestine, kidneys and bones) and placental involvement, showing a monophasic histological pattern through the lesions during the course of disease. Histologically, the tumor was composed of a solid proliferation of cytologically uniform, \u2018primitive\u2019 mesenchymal cells associated with a hemangiopericytoma\u2010like vascular pattern. Immunohistochemical analysis and ultrastructural study revealed that the tumor cells exhibited primitive features without mature myofibroblastic differentiation. Neither <jats:styled-content style=\"fixed-case\">ETV6\u2010NTRK3<\/jats:styled-content> nor <jats:styled-content style=\"fixed-case\">ACTB\u2010GLI<\/jats:styled-content> fusion gene was identified. The patient died of cerebral hemorrhage and respiratory failure at four months of age despite intensive therapy. Generalized <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> characterized by monophasic primitive pattern could be related to poor clinical outcome.<\/jats:p>","DOI":"10.1111\/pin.12312","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T07:54:16Z","timestamp":1432108456000},"page":"432-437","source":"Crossref","is-referenced-by-count":6,"title":["Generalized infantile myofibromatosis with a monophasic primitive pattern"],"prefix":"10.1111","volume":"65","author":[{"given":"Hideto","family":"Iwafuchi","sequence":"first","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Pathology Shizuoka Children's Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagoya Daini Red Cross Hospital  Nagoya 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