{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:45:56Z","timestamp":1757310356326},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Epithelial\u2010myoepithelial carcinoma (<jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content>) is a rare salivary gland tumor with a low\u2010grade malignancy, and <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content> with high\u2010grade histopathological features is exceedingly rare. Furthermore, <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content> with intracellular mucin is also extremely rare. We report an uncommon case of a high\u2010grade <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content> of the parotid gland with mucous cell differentiation in a 66\u2010year old Japanese woman who noticed a right palpable parotid mass increasing in size within a one\u2010year period. The cytological specimen showed a focally biphasic structure and included isolated or discohesive piled\u2010up clusters with hyaline globules surrounded by neoplastic cells with nuclear atypia. The gross examination revealed a relatively well\u2010demarcated, multinodular gray\u2010whitish and solid mass. Histologically, the tumor consisted of variably sized solid nests or trabeculae with central necrosis and increased mitotic activity, and invaded into adjacent skeletal muscles. Immunohistochemically, the biphasic ductal and myoepithelial differentiation of this tumor confirmed the diagnosis of high\u2010grade <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content>. Furthermore, numerous small nests with d\u2010<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> and alcian blue\u2010positive mucous cells predominated in about 5% of the whole tumor, and these mucous cells were encompassed by neoplastic myoepithelial cells. We should recognize this variant of <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content> because we can't rule out the possibility of <jats:styled-content style=\"fixed-case\">EMC<\/jats:styled-content> even in the presence of mucous cells.<\/jats:p>","DOI":"10.1111\/pin.12315","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T01:23:29Z","timestamp":1433381009000},"page":"490-494","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010grade epithelial\u2010myoepithelial carcinoma of the parotid gland with mucous cell differentiation"],"prefix":"10.1111","volume":"65","author":[{"given":"Kazuhiro","family":"Sentani","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Center of Oral Clinical Examination Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Uraoka","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Miyoshi Central Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Miyoshi Central Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohide","family":"Oue","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathobiology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"225","volume-title":"World Health Organization Classification of Tumours. 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