{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:34:33Z","timestamp":1780774473899,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Subependymoma is a rare subtype of benign ependymal neoplasm with distinct histological features. Anaplastic transformation has not yet been reported in this tumor to date. We present here a very unusual case of a 62\u2010year\u2010old woman with recurrent subependymoma of the fourth ventricle with multiple atypical histological features. Histologically, the resected recurrent tumor showed characteristic small cell clusters and nests of ependymal cells with an interspersed gliofibrillary matrix as seen in a classic subependymoma. In addition, there were very unusual histological features, including multiple areas of necrosis, microvascular proliferation, thrombosed blood vessels, and scattered mitotic figures. No coexisting ependymoma component of higher World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) grade was present. Immunohistochemically, <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index was high, with up to 15% in the highest areas. Review of this patient's initial tumor, which was resected 6 years prior to recurrence, demonstrated features of a typical classic subependymoma without atypical features or a secondary tumor component. Subependymomas are known to be low\u2010grade tumors and are usually cured if completely excised. The tumor presented here is unique in that several atypical pathological features were found in an otherwise typical subependymoma. Our case may represent anaplastic transformation of subependymoma, although no such examples have been reported to date.<\/jats:p>","DOI":"10.1111\/pin.12316","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T03:39:45Z","timestamp":1433993985000},"page":"438-442","source":"Crossref","is-referenced-by-count":10,"title":["Recurrent subependymoma of fourth ventricle with unusual atypical histological features: A case report"],"prefix":"10.1111","volume":"65","author":[{"given":"Nishant","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Z.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9411-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.5.7572512"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.4.2107685"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000209928.04532.09"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.331125192"},{"key":"e_1_2_7_7_1","first-page":"70","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis DN","year":"2007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5858\/1999-123-0306-S","article-title":"Subependymomas: Clinicopathologic study of 14 tumors, including comparative MIB\u20101 immunohistochemical analysis with other ependymal neoplasms","volume":"123","author":"Prayson RA","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS14155"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689604"},{"key":"e_1_2_7_11_1","first-page":"63","article-title":"Subependymoma of the third ventricle after partial resection of a craniopharyngioma and repeated postoperative irradiation","volume":"15","author":"Tolnay M","year":"1996","journal-title":"Clin Neuropathol"},{"key":"e_1_2_7_12_1","first-page":"12","article-title":"Craniopharyngioma and \u2018reactive\u2019 subependymoma of the third ventricle\u2014a case report","volume":"6","author":"Ho KC","year":"1987","journal-title":"Clin Neuropathol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/NPP26037"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023357810796"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:26:23Z","timestamp":1695551183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/pin.12316"],"URL":"https:\/\/doi.org\/10.1111\/pin.12316","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}