{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:00:19Z","timestamp":1775059219634,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,9]]},"abstract":"We experienced a case of intraductal tubulopapillary neoplasms (ITPN<\/jats:styled-content>) of the pancreas with severe calcification, which complicated image diagnosis. A pancreas head tumor was detected in a J<\/jats:styled-content>apanese female in her 50s. Early enhancement by contrast\u2010enhanced CT<\/jats:styled-content> and coarse calcification suggested a neuroendocrine tumor, although the obstruction and dilation of the main pancreatic duct appeared to be an intraductal tumor. An endoscopic ultrasound\u2010guided fine needle aspiration biopsy specimen revealed adenocarcinoma tissue. Pancreaticoduodenectomy was performed, and the patient has been well without evidence of recurrence for over 10 months. Pathological examination on the resected specimen revealed that the tumor showed papillary and tubulo\u2010cribriform growth patterns. Together with typical immunohistochemical results, the final diagnosis of ITPN<\/jats:styled-content> was made. Characteristically, this case showed extensive calcification of both psammoma body\u2010type and non psammoma body\u2010type with foamy macrophage aggregation. This is the first report of ITPN<\/jats:styled-content> with two types of calcification and macrophage. Since calcification might be one of the characteristic histological findings in ITPN<\/jats:styled-content> as shown in our case, the possibility of ITPN<\/jats:styled-content> should be also considered when calcification is detected in pancreatic lesions by various imaging modalities.<\/jats:p>","DOI":"10.1111\/pin.12322","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T08:31:19Z","timestamp":1435566679000},"page":"501-506","source":"Crossref","is-referenced-by-count":14,"title":["A case of intraductal tubulopapillary neoplasm of pancreas with severe calcification, a potential pitfall in diagnostic imaging"],"prefix":"10.1111","volume":"65","author":[{"given":"Shouichi","family":"Takayama","sequence":"first","affiliation":[{"name":"Department of Surgery Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Department of Surgery Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyon Su","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Surgery Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Surgery Moriguchi Keijinkai Hospital Moriguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"304","volume-title":"World Health Organization Classification of 14 Tumours of the Digestive System","author":"Adsay NV","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31826d1fc8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a162e5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02791.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5833\/jjgs.2011.0312"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23083"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2958\/suizo.29.729"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.09.2011.4777"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2012.09.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.80.224"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746\u20101596\u20109\u201011"},{"key":"e_1_2_7_13_1","volume-title":"General Rules for the Study of Pancreatic Cancer","author":"Japan Pancreas Society","year":"2009"},{"key":"e_1_2_7_14_1","first-page":"1003","article-title":"Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. 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