{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:33:44Z","timestamp":1773290024263,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Cervical cancer is the third most common cancer in women worldwide. The hypermethylation of P<\/jats:styled-content>16<\/jats:italic>, TSLC<\/jats:styled-content>\u20101<\/jats:italic> and TSP<\/jats:styled-content>\u20101<\/jats:italic> genes was analyzed in squamous cell carcinomas (SCC<\/jats:styled-content>), cervical intraepithelial lesions (CIN<\/jats:styled-content>) and adenocarcinomas (ADC<\/jats:styled-content>) of the uterine cervix (total 181 lesions). Additionally human papillomavirus (HPV<\/jats:styled-content>) type, EPB41L3<\/jats:styled-content>, RASSF1<\/jats:styled-content><\/jats:italic> and RASSF2<\/jats:styled-content><\/jats:italic> hypermethylation were tested in ADC<\/jats:styled-content> and the results were compared with those obtained previously by our group in SCC<\/jats:styled-content>. P<\/jats:styled-content>16<\/jats:italic>, TSLC<\/jats:styled-content>\u20101<\/jats:italic> and TSP<\/jats:styled-content>\u20101<\/jats:italic> hypermethylation was more frequent in SCCs<\/jats:styled-content> than in CINs<\/jats:styled-content>. These percentages and the corresponding ones for EPB41L3<\/jats:styled-content><\/jats:italic>, RASSF1<\/jats:styled-content><\/jats:italic> and RASSF2<\/jats:styled-content><\/jats:italic> genes were also higher in SCCs<\/jats:styled-content> than in ADCs<\/jats:styled-content>, except for P<\/jats:styled-content>16<\/jats:italic>. The presence of HPV<\/jats:styled-content> in ADCs<\/jats:styled-content> was lower than reported previously in SCC<\/jats:styled-content> and CIN<\/jats:styled-content>. Patients with RASSF1A<\/jats:styled-content><\/jats:italic> hypermethylation showed significantly longer disease\u2010free survival (P<\/jats:italic> = 0.015) and overall survival periods (P<\/jats:italic> = 0.009) in ADC<\/jats:styled-content> patients. To our knowledge, this is the first description of the EPB41L3<\/jats:styled-content><\/jats:italic> and RASSF2<\/jats:styled-content><\/jats:italic> hypermethylation in ADCs<\/jats:styled-content>. These results suggest that the involvement of DNA<\/jats:styled-content> hypermethylation in cervical cancer varies depending on the histological type, which might contribute to explaining the different prognosis of patients with these types of tumors.<\/jats:p>","DOI":"10.1111\/pin.12332","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T09:39:53Z","timestamp":1437989993000},"page":"476-485","source":"Crossref","is-referenced-by-count":12,"title":["Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix"],"prefix":"10.1111","volume":"65","author":[{"given":"Idoia","family":"Blanco\u2010Luquin","sequence":"first","affiliation":[{"name":"Cancer Epigenetics Group Navarrabiomed\u2010Fundaci\u00f3n Miguel Servet Instituto de Investigaciones Sanitarias de Navarra\u2010IdiSNA Pamplona Spain"},{"name":"Cancer Immunomodulation Group Navarrabiomed\u2010Fundaci\u00f3n 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