{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:15:29Z","timestamp":1761844529478},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Translocations involving MYC<\/jats:styled-content><\/jats:italic> are highly characteristic for B<\/jats:styled-content>urkitt lymphoma (BL<\/jats:styled-content>). BCL2<\/jats:styled-content> expression has also been found previously in about 10 to 20% of BL<\/jats:styled-content> cases, and BCL2<\/jats:styled-content><\/jats:italic> translocation is a major mechanism for the deregulation of BCL2<\/jats:styled-content> expression in non\u2010H<\/jats:styled-content>odgkin lymphomas. However, we know little about the incidence of MYC<\/jats:italic>\/BCL2<\/jats:italic><\/jats:styled-content> double\u2010hit (DH<\/jats:styled-content>) in BL<\/jats:styled-content>. We examined BL<\/jats:styled-content> cases to determine how frequently they contained BCL2<\/jats:styled-content><\/jats:italic> translocations in combination with MYC<\/jats:styled-content><\/jats:italic> translocations using fluorescence in situ<\/jats:italic> hybridization. We also determined the effect of BCL2<\/jats:styled-content> expression on clinical outcomes of BL<\/jats:styled-content>. BCL2<\/jats:styled-content><\/jats:italic> translocations were detected in 3.5% (2\/57 cases) of the cases, and BCL2<\/jats:styled-content> expression was detected in 33%. Two cases with BCL2<\/jats:styled-content><\/jats:italic> translocation also showed BCL2<\/jats:styled-content> expression. The incidence of BCL2<\/jats:styled-content> expression was significantly higher in patients 16 years of age and older (46%) than in patients under 16 years of age (6%). Among patients 16 years of age and older, we did not detect significant differences in overall survival with respect to BCL2<\/jats:styled-content> expression status. In conclusion, BCL2<\/jats:styled-content><\/jats:italic> translocation is a rare cytogenetic abnormality in BL<\/jats:styled-content>, and BL<\/jats:styled-content> probably accounts for only a small fraction of MYC<\/jats:italic>\/BCL2<\/jats:italic> DH<\/jats:styled-content> lymphomas. BCL2<\/jats:styled-content> expression in BL<\/jats:styled-content> is probably not associated with BCL2<\/jats:styled-content><\/jats:italic> translocations.<\/jats:p>","DOI":"10.1111\/pin.12333","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T04:17:33Z","timestamp":1437106653000},"page":"486-489","source":"Crossref","is-referenced-by-count":2,"title":["Low incidence of MYC<\/i>\/BCL2<\/i><\/scp> double\u2010hit in B<\/scp>urkitt lymphoma"],"prefix":"10.1111","volume":"65","author":[{"given":"Maki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kiyasu","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshizo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Niino","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212191"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_7_4_1","first-page":"267","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00851.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000019577.73786.64"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"WeremowiczS SchofieldDE.Preparation of cells from formalin\u2010fixed paraffin\u2010embedded tissue for use in fluorescence in situ hybridization (FISH) experiments.Curr Protoc Hum Genet2007. 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