{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:35:03Z","timestamp":1781822103599,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Double\u2010hit (DH<\/jats:styled-content>) lymphomas are B<\/jats:styled-content>\u2010cell lymphomas characterized by chromosomal rearrangements, specifically of MYC<\/jats:styled-content><\/jats:italic> and either BCL<\/jats:styled-content>2<\/jats:italic>, BCL<\/jats:styled-content>6<\/jats:italic> or CCND<\/jats:styled-content>1<\/jats:italic>. We reviewed 22 cases of DH<\/jats:styled-content> lymphomas. BCL<\/jats:styled-content>2<\/jats:italic>\/MYC<\/jats:styled-content><\/jats:italic>\u2005DH<\/jats:styled-content> lymphomas constituted the majority of these DH<\/jats:styled-content> lymphomas (17 cases; 77%), followed by BCL<\/jats:styled-content>6<\/jats:italic>\/MYC<\/jats:styled-content><\/jats:italic> (2 cases; 9%) lymphomas. Assessing morphological features using the 2008 World Health Organization classification system, 15 cases (68%) were determined to be B<\/jats:styled-content>\u2010cell lymphoma, unclassifiable with features intermediate between diffuse large B<\/jats:styled-content>\u2010cell lymphoma (DLBCL<\/jats:styled-content>) and Burkitt lymphoma (BCLU<\/jats:styled-content>) (10 cases; 45%), or as DLBCL<\/jats:styled-content> (5 cases; 23%), and 2 cases (9%) were classified as morphologically untransformed follicular lymphoma. Burkitt lymphoma was rare (1 case; 5%) among DH<\/jats:styled-content> lymphomas. Nineteen cases were treated with R\u2010CHOP or a high dose chemotherapy regimen. After a median follow\u2010up of 11 months, 7 patients had died, and the 1\u2010year survival rate was 62.5%. High dose chemotherapy did not improve the outcome. We suggest that screening of genetic variations to detect DH<\/jats:styled-content> lymphomas is required in diagnosing all lymphomas, even those determined morphologically to be follicular lymphoma.<\/jats:p>","DOI":"10.1111\/pin.12335","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T06:23:31Z","timestamp":1438151011000},"page":"519-527","source":"Crossref","is-referenced-by-count":25,"title":["Clinicopathological features of double\u2010hit B<\/scp>\u2010cell lymphomas with MYC<\/scp><\/i> and BCL<\/scp>2<\/i>, BCL<\/scp>6<\/i> or CCND<\/scp>1<\/i> rearrangements"],"prefix":"10.1111","volume":"65","author":[{"given":"Maki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kiyasu","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshizo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Fukuoka 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