{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:19:08Z","timestamp":1780474748304,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Patients having rheumatoid arthritis (RA<\/jats:styled-content>) treated with methotrexate (MTX<\/jats:styled-content>) are at an increased risk of developing lymphoproliferative disorder (LPD<\/jats:styled-content>). E<\/jats:styled-content>pstein\u2013B<\/jats:styled-content>arr virus (EBV<\/jats:styled-content>) sometimes contributes to the development of MTX<\/jats:styled-content>\u2010associated LPD<\/jats:styled-content>. Herein, we report the case of a 64\u2010year\u2010old J<\/jats:styled-content>apanese woman with RA<\/jats:styled-content> who showed complications of EBV<\/jats:styled-content>\u2010positive MTX<\/jats:styled-content>\u2010associated LPD<\/jats:styled-content>. This case is exceedingly rare in that the LPD<\/jats:styled-content> was confined to the lungs and its subclassification was extranodal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma. Only four cases of extranodal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma in the setting of MTX<\/jats:styled-content>\u2010associated LPD<\/jats:styled-content> have ever been reported in the E<\/jats:styled-content>nglish language literature, only one of which was an extranasal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma, similar to our case. Extranasal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphomas show more aggressive behavior than nasal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphomas, possibly reflected by the considerable re\u2010exacerbation of the lesions in only two months after the cessation of MTX<\/jats:styled-content> in our case. However, the SMILE<\/jats:styled-content> regimen (steroid, methotrexate, ifosfamide, l\u2010asparaginase, and etoposide) was able to suppress tumor growth in this case.<\/jats:p>","DOI":"10.1111\/pin.12346","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T21:50:46Z","timestamp":1444773046000},"page":"661-665","source":"Crossref","is-referenced-by-count":17,"title":["Methotrexate\u2010associated lymphoproliferative disorder presenting as extranodal NK<\/scp>\/T<\/scp>\u2010cell lymphoma arising in the lungs"],"prefix":"10.1111","volume":"65","author":[{"given":"Shogo","family":"Tajima","sequence":"first","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takanashi","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery Fujieda Municipal General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Koda","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujieda Municipal General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.6.1943"},{"key":"e_1_2_6_3_1","first-page":"350","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Gaulard P","year":"2008"},{"key":"e_1_2_6_4_1","first-page":"322","article-title":"Lymphoproliferative disorders in rheumatoid arthritis: Clinicopathological analysis of 76 cases in relation to methotrexate medication","volume":"34","author":"Hoshida Y","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_1","first-page":"77","article-title":"Nasal type extranodal NK\/T cell lymphoma diagnosed in a patient with rheumatoid arthritis under methotrexate","volume":"39","author":"Terroso G","year":"2014","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1389-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.03.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3153"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1562"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001101)88:3<497::AID-IJC27>3.0.CO;2-J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920060-00002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.05.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22579"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22306"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80049-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12116"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b25.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-185256"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1189-4"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:07:23Z","timestamp":1695503243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/pin.12346"],"URL":"https:\/\/doi.org\/10.1111\/pin.12346","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}