{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:17:42Z","timestamp":1787847462192,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"A 41\u2010year\u2010old male patient with a history of ankylosing spondylitis and C<\/jats:styled-content>rohn disease, treated with immunomodulators and disease\u2010modifying drugs, was diagnosed with a primary intestinal T<\/jats:styled-content>\u2010cell lymphoma that followed a 7.5\u2010year\u2010course. This transmural proliferation lacked cytological characteristics of anaplastic large cell lymphoma (ALCL<\/jats:styled-content>), and was CD<\/jats:styled-content>8\u2010positive, and CD<\/jats:styled-content>30\u2010 and anaplastic lymphoma kinase (ALK<\/jats:styled-content>)\u2010negative by immunohistochemistry (IHC<\/jats:styled-content>). However, ALK<\/jats:styled-content>\u2010gene rearrangement (ALK<\/jats:styled-content>\u2010gr) was detected by fluorescence in situ<\/jats:italic> hybridization (FISH<\/jats:styled-content>) in both initial and persistent disease. The possibility of indolent T\u2010cell lymphoproliferative disease of the gastrointestinal tract with atypical features (transmural involvement) related to ALK<\/jats:styled-content>\u2010gr was suggested. A previous case of aggressive \u2018enteropathy\u2010associated ALCL<\/jats:styled-content>\u2019 in the context of celiac disease was recently reported, which also lacked anaplastic morphology, and where CD<\/jats:styled-content>30 and ALK<\/jats:styled-content> expression was incidentally demonstrated by IHC<\/jats:styled-content>, and ALK<\/jats:styled-content>\u2010gr subsequently confirmed by FISH<\/jats:styled-content>. These two recent cases represent two distinct rare entities pertaining to the group of primary intestinal T\u2010cell lymphomas, and they both show unexpected ALK<\/jats:styled-content>\u2010gr. This suggests that ALK<\/jats:styled-content>\u2010gr has been overlooked in the group of primary intestinal T<\/jats:styled-content>\u2010cell lymphomas. Performing IHC<\/jats:styled-content> and FISH<\/jats:styled-content> tests for ALK<\/jats:styled-content>\u2010gr in primary gastrointestinal T<\/jats:styled-content>\u2010cell lymphomas might be of importance, particularly with the advancement of targeted therapy that could impact treatment and prognosis.<\/jats:p>","DOI":"10.1111\/pin.12358","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T09:01:51Z","timestamp":1446627711000},"page":"666-670","source":"Crossref","is-referenced-by-count":3,"title":["Is ALK<\/scp>\u2010gene rearrangement overlooked in primary gastrointestinal T<\/scp>\u2010cell lymphomas? 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