{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:23:15Z","timestamp":1761578595385},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Lung adenocarcinoma is a highly heterogeneous disease and the heterogeneity is associated with various patient outcomes even in early\u2010stage tumors. In order to improve prognostic and predictive values, the IASLC<\/jats:styled-content>\/ATS<\/jats:styled-content>\/ERS<\/jats:styled-content> international multidisciplinary lung adenocarcinoma classification was put forth in 2011 and it has been adopted in the recently published World Health Organization (WHO<\/jats:styled-content>) classification of T<\/jats:styled-content>umours of the L<\/jats:styled-content>ung, P<\/jats:styled-content>leura, T<\/jats:styled-content>hymus and H<\/jats:styled-content>eart 4th edition 2015, and lung adenocarcinomas are classified based on the predominant pattern. The performance of the classification in stratifying patient outcomes after resection of Stage I<\/jats:styled-content> tumors and predicting molecular alterations has been confirmed by several studies. It also includes the category of minimally invasive adenocarcinoma (MIA<\/jats:styled-content>) that predicts 100% 5\u2010year recurrence free survival after curative resection similar to adenocarcinoma in situ<\/jats:italic>. The diagnosis of MIA<\/jats:styled-content> is based on not only size of the invasive component but also the absence of aggressive morphologic features such as pleural and\/or lymphovascular invasion. Importantly, the WHO<\/jats:styled-content> 2015 classification has introduced the concept of air space invasion and includes it as the exclusion criteria for MIA<\/jats:styled-content>. The air space invasion consists of tumor islands and spread through air spaces (STAS<\/jats:styled-content>). In this review, we will discuss the two entities and their clinical implications.<\/jats:p>","DOI":"10.1111\/pin.12368","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T10:18:03Z","timestamp":1449656283000},"page":"1-7","source":"Crossref","is-referenced-by-count":36,"title":["Tumor islands and spread through air spaces: Distinct patterns of invasion in lung adenocarcinoma"],"prefix":"10.1111","volume":"66","author":[{"given":"Vicente","family":"Morales\u2010Oyarvide","sequence":"first","affiliation":[{"name":"Departments of Medical Oncology Dana\u2010Farber Cancer Institute and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Mino\u2010Kenudson","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"GLOBOCAN.Globocan IARC Fact Sheets.2012. 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